CAS 147511-69-1

Pitavastatin

Description:

Pitavastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its mechanism of action involves the inhibition of HMG-CoA reductase, an enzyme critical in the cholesterol biosynthesis pathway, leading to decreased levels of low-density lipoprotein (LDL) cholesterol in the bloodstream. Pitavastatin is characterized by its high potency and relatively favorable pharmacokinetic profile, including a longer half-life compared to some other statins, which allows for once-daily dosing. It is also noted for its ability to improve endothelial function and may have additional pleiotropic effects beyond cholesterol reduction. The substance is typically administered orally and is well-absorbed, with its bioavailability influenced by food intake. Common side effects may include muscle pain, liver enzyme elevations, and gastrointestinal disturbances, although it is generally well-tolerated. As with other statins, monitoring liver function and muscle-related symptoms is recommended during treatment.

Formula: C₂₅H₂₄FNO₄

InChI: InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1

InChI key: InChIKey=VGYFMXBACGZSIL-MCBHFWOFSA-N

SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C1=C(C2=C(N=C1C3CC3)C=CC=C2)C4=CC=C(F)C=C4

Synonyms:

• (+)-(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid
• (3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
• (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid
• (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-
• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, [S-[R*,S*-(E)]]-
• Itavastatin
• Monocalciumbis{(3R,5S,6E)-7-[2-Cyclopyl-4-(4-Fluorophenyl)-3-Quinolyl]-3,5-Dihydroxy-6-Heptenoate}
• Nk 104
• Pitavastatin Acid
• Pitvastatin

6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-

CAS: 147511-69-1

Formula: C₂₅H₂₄FNO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 421.4608

Ref: IN-DA001EXH

Pitavastatin

CAS: 147511-69-1

Pitavastatin

Purity: ≥95%

Molecular weight: 421.46g/mol

Ref: 54-BUP06826

Pitavastatin-d5 Sodium Salt

Controlled Product

CAS: 147511-69-1

Applications Labelled Pitavastatin. A HMG CoA reductase inhibitor. An antilipemic.
References Yen, H., et al.: J. Clin. Invest., 98, 1253 (1996), Zou, Y., et al.: J. Biol. Chem., 274, 9760 (1999), Sun, X., et al.: Cancer Res., et al.: 61, 3382 (2001), Ladas, E.J., et al.: Clin. Oncol., 22, 517 (2004),

Formula: C₂₅H₁₈D₅FNNaO₄

Color and Shape: White To Off-White

Molecular weight: 448.47

Ref: TR-P531007

Pitavastatin

CAS: 147511-69-1

Pitavastatin (NK-104) is an HMG-CoA reductase inhibitor with hypocholesterolemic and neuroprotective activities.

Formula: C₂₅H₂₄FNO₄

Purity: 97.17%

Color and Shape: Solid

Molecular weight: 421.46

Ref: TM-T7072

Pitavastatin

CAS: 147511-69-1

Inhibitor of HMG-CoA reductase

Formula: C₂₅H₂₄FNO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 421.46 g/mol

Ref: 3D-FP65047