CAS 147511-69-1: Pitavastatin

Description: Pitavastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its mechanism of action involves the inhibition of HMG-CoA reductase, an enzyme critical in the cholesterol biosynthesis pathway, leading to decreased levels of low-density lipoprotein (LDL) cholesterol in the bloodstream. Pitavastatin is characterized by its high potency and relatively favorable pharmacokinetic profile, including a longer half-life compared to some other statins, which allows for once-daily dosing. It is also noted for its ability to improve endothelial function and may have additional pleiotropic effects beyond cholesterol reduction. The substance is typically administered orally and is well-absorbed, with its bioavailability influenced by food intake. Common side effects may include muscle pain, liver enzyme elevations, and gastrointestinal disturbances, although it is generally well-tolerated. As with other statins, monitoring liver function and muscle-related symptoms is recommended during treatment.

Formula: C₂₅H₂₄FNO₄

InChI: InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/b12-11+/t18-,19-/m1/s1

InChI key: InChIKey=VGYFMXBACGZSIL-MCBHFWOFSA-N

SMILES: O=C(O)CC(O)CC(O)C=CC=1C(=NC=2C=CC=CC2C1C=3C=CC(F)=CC3)C4CC4

Synonyms:

• (+)-(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid
• (3R,5S,6E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid
• (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid
• (6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-
• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, [S-[R*,S*-(E)]]-
• Itavastatin
• Monocalciumbis{(3R,5S,6E)-7-[2-Cyclopyl-4-(4-Fluorophenyl)-3-Quinolyl]-3,5-Dihydroxy-6-Heptenoate}
• Nk 104
• Pitavastatin Acid
• Pitvastatin
• Pitavastatin

6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-

CAS: 147511-69-1

• Formula: C₂₅H₂₄FNO₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 421.4608

Pitavastatin

CAS: 147511-69-1

• Purity: 97.17%
• Molecular weight: 421.46g/mol

Pitavastatin

CAS: 147511-69-1

Pitavastatin (NK-104) is an HMG-CoA reductase inhibitor with hypocholesterolemic and neuroprotective activities.

• Formula: C₂₅H₂₄FNO₄
• Purity: 97.17%
• Color and Shape: Solid
• Molecular weight: 421.46

Pitavastatin-d5 Sodium Salt

CAS: 147511-69-1

Applications Labelled Pitavastatin. A HMG CoA reductase inhibitor. An antilipemic. References Yen, H., et al.: …

• Formula: C₂₅H₁₈D₅FNNaO₄
• Color and Shape: White To Off-White
• Molecular weight: 448.47

Pitavastatin

CAS: 147511-69-1

Inhibitor of HMG-CoA reductase

• Formula: C₂₅H₂₄FNO₄
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 421.46 g/mol