CAS 147526-32-7

Pitavastatin calcium

Description:

Pitavastatin calcium is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. It functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby lowering levels of low-density lipoprotein (LDL) cholesterol and triglycerides while modestly increasing high-density lipoprotein (HDL) cholesterol. The compound is characterized by its calcium salt form, which enhances its solubility and bioavailability. Pitavastatin is typically administered orally and exhibits a relatively long half-life, allowing for once-daily dosing. It is known for its favorable pharmacokinetic profile, including minimal drug-drug interactions compared to other statins. Common side effects may include muscle pain, gastrointestinal disturbances, and liver enzyme elevations, necessitating monitoring during treatment. As with other statins, it is contraindicated in certain populations, such as those with active liver disease or during pregnancy. Overall, Pitavastatin calcium is an effective option in the management of dyslipidemia, contributing to improved cardiovascular health outcomes.

Formula: C₅₀H₄₆CaF₂N₂O₈

InChI: InChI=1/2C25H25FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,23,28-30H,5-6,13-14H2;/q2*-1;+2/b2*12-11+;/t2*18-,19-,23+;/m11./s1

InChI key: InChIKey=AMUDYCAFPCQTAZ-NRFPMOEYSA-N

SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C1=C(C2=C(N=C1C3CC3)C=CC=C2)C4=CC=C(F)C=C4.[Ca]

Synonyms:

• (+)-Monocalciumbis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-,5-dihydroxy-6-heptenoate}
• (+)-Monocalciumbis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}
• (E)-(3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-
• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt (2:1), [S-[R*,S*-(E)]]-
• Calcium (E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
• Flovas
• Livalo
• NK 104 (acid)
• Nk 104
• Pitava
• Pitava 1
• Pitavastatin hemicalcium
• calcium bis{(1R,3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-1,3,5-trihydroxyhept-6-en-1-olate}
• D01862
• nk104(acid)
• monocalciumbis[(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl)-3,5-Dihydroxy-6-heptenoate](+)α-Phenethylamine Salt
• nk104
• ITAVASTATIN CALCIUM
• 6-heptenoicacid,7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydro
• PITAVASTATIN CALCIUM
• Pitavasttin Calcium
• calciumsalt(2:1),(3r,5s,6e)-xy
• PITAVASTATINCALCIUM(FORR&DONLY)
• ITAVASTATIN CA

Pitavastatin Calcium (contains 15% Water at maximum)

CAS: 147526-32-7

Formula: C₅₀H₄₆CaF₂N₂O₈

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 881.00

Ref: 3B-P2071

6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-

CAS: 147526-32-7

Formula: C₅₀H₄₆CaF₂N₂O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 880.9836

Ref: IN-DA001EYE

Pitavastatin-d4 Calcium Salt

CAS: 147526-32-7

Formula: C₂₅H₁₉D₄FNO₄·Ca

Color and Shape: White To Off-White Solid

Molecular weight: 2*424.49 40.08

Ref: 4Z-P-645

Pitavastatin calcium

CAS: 147526-32-7

Pitavastatin calcium

Purity: 98%

Molecular weight: 881.01g/mol

Ref: 54-IN12073

Pitavastatin Calcium Salt

CAS: 147526-32-7

Formula: C₂₅H₂₃FNO₄·Ca

Color and Shape: White To Off-White Solid

Molecular weight: 2*420.46 40.08

Ref: 4Z-P-641

Pitavastatin calcium salt

CAS: 147526-32-7

Formula: C₂₅H₂₃FNO₄·5Ca

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White to pale yellow powder

Molecular weight: 440.50

Ref: 7W-GP8116

Pitavastatin calcium

CAS: 147526-32-7

Pitavastatin calcium

Purity: ≥98%

Molecular weight: 880.98g/mol

Ref: 54-BUP13366

Pitavastatin Calcium

CAS: 147526-32-7

Formula: C₂₅H₂₃FNO₄·Ca

Color and Shape: Neat

Molecular weight: 880.98

Ref: 86-MM3741.00

Pitavastatin calcium

CAS: 147526-32-7

Pitavastatin calcium (NK-104), a inhibitor of HMG-CoA reductase, lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans.

Formula: C₅₀H₄₆CaF₂N₂O₈

Purity: 98.89% - >99.99%

Color and Shape: White To Off-White Powder

Molecular weight: 880.98

Ref: TM-T2534

Pitavastatin Calcium

CAS: 147526-32-7

Stability Hygroscopic
Applications A competitive inhibitor of HMG-CoA reductase. Antilipemic.
References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),

Formula: C₂₅H₂₃FNO₄·Ca

Color and Shape: White To Off-White

Molecular weight: 880.98

Ref: TR-P531000

Pitavastatin calcium

CAS: 147526-32-7

Inhibitor of HMG-CoA reductase

Formula: C₅₀H₄₆F₂N₂O₈Ca

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 880.98 g/mol

Ref: 3D-FP37016

Pitavastatin Calcium

CAS: 147526-32-7

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Formula: Ca(C₂₅H₂₃FNO₄)₂

Molecular weight: 880.28481

Ref: 45-1544701