CAS 147536-97-8: Bosentan
Description:Bosentan is a dual endothelin receptor antagonist primarily used in the treatment of pulmonary arterial hypertension (PAH). It works by blocking the effects of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure in the pulmonary arteries. The chemical formula of bosentan is C27H29N5O3S, and it features a sulfonamide group, which contributes to its pharmacological activity. Bosentan is typically administered orally and is known for its relatively long half-life, allowing for once or twice daily dosing. It is also associated with potential side effects, including liver enzyme elevations and teratogenic effects, necessitating regular monitoring of liver function and pregnancy status in patients. Due to its mechanism of action, bosentan can improve exercise capacity and overall quality of life in individuals with PAH. Additionally, it is classified as a pregnancy category X drug, indicating that it should not be used during pregnancy due to risks to the fetus.
Formula:C27H29N5O6S
InChI:InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
InChI key:InChIKey=GJPICJJJRGTNOD-UHFFFAOYSA-N
SMILES:O=S(=O)(NC=1N=C(N=C(OCCO)C1OC=2C=CC=CC2OC)C3=NC=CC=N3)C4=CC=C(C=C4)C(C)(C)C
- Synonyms:
- 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]benzenesulfonamide
- 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
- Act 434964
- Actelion
- Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-
- N-[6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-2-Pyrimidin-2-Yl-Pyrimidin-4-Yl]-4-Tert-Butyl-Benzenesulfonamide
- Ro 47-0203
- Ro 47-0203/039
- Tracleer
- p-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
- See more synonyms
- Bosentan
