CAS 147536-97-8

Bosentan

Description:

Bosentan is a dual endothelin receptor antagonist primarily used in the treatment of pulmonary arterial hypertension (PAH). It works by blocking the effects of endothelin-1, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure in the pulmonary arteries. The chemical formula of bosentan is C27H29N5O3S, and it features a sulfonamide group, which contributes to its pharmacological activity. Bosentan is typically administered orally and is known for its relatively long half-life, allowing for once or twice daily dosing. It is also associated with potential side effects, including liver enzyme elevations and teratogenic effects, necessitating regular monitoring of liver function and pregnancy status in patients. Due to its mechanism of action, bosentan can improve exercise capacity and overall quality of life in individuals with PAH. Additionally, it is classified as a pregnancy category X drug, indicating that it should not be used during pregnancy due to risks to the fetus.

Formula: C₂₇H₂₉N₅O₆S

InChI: InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)

InChI key: InChIKey=GJPICJJJRGTNOD-UHFFFAOYSA-N

SMILES: O(C=1C(NS(=O)(=O)C2=CC=C(C(C)(C)C)C=C2)=NC(=NC1OCCO)C=3N=CC=CN3)C4=C(OC)C=CC=C4

Synonyms:

• 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]benzenesulfonamide
• 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide
• Act 434964
• Actelion
• Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-
• N-[6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-2-Pyrimidin-2-Yl-Pyrimidin-4-Yl]-4-Tert-Butyl-Benzenesulfonamide
• Ro 47-0203
• Ro 47-0203/039
• Tracleer
• p-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
• Bosentan

Bosentan Monohydrate

CAS: 147536-97-8, 157212-55-0

Formula: C₂₇H₂₉N₅O₆S·H₂O

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 569.64

Ref: 3B-B5118

Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-

CAS: 147536-97-8

Formula: C₂₇H₂₉N₅O₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 551.6141

Ref: IN-DA001EY6

Bosentan

CAS: 147536-97-8

Formula: C₂₇H₂₉N₅O₆S

Color and Shape: White To Off-White Solid

Molecular weight: 551.62

Ref: 4Z-B-121

Bosentan

CAS: 147536-97-8

Bosentan

Purity: ≥98%

Molecular weight: 551.614g/mol

Ref: 54-BUP15718

Bosentan

CAS: 147536-97-8

Bosentan is a competitive endothelin receptor antagonist, used for treating pulmonary arterial hypertension.

Formula: C₂₇H₂₉N₅O₆S

Purity: 99.74% - 99.84%

Color and Shape: Pale Yellow To Off-White Solid

Molecular weight: 551.614

Ref: TM-T6264

4-(TERT-BUTYL)-N-(6-(2-HYDROXYETHOXY)-5-(2-METHOXYPHENOXY)-[2,2'-BIPYRIMIDIN]-4-YL)BENZENESULFONAMIDE

CAS: 147536-97-8

Purity: 95%

Molecular weight: 551.619995117188

Ref: 10-F802473

Bosentan

Controlled Product

CAS: 147536-97-8

Formula: C₂₇H₂₉N₅O₆S

Color and Shape: Off White

Molecular weight: 551.61

Ref: TR-B675900

Bosentan - Bio-X ™

CAS: 147536-97-8

Bosentan is a dual endothelin receptor antagonist that is used to treat hypertension. This drug works by blocking the action of endothelin molecules which prevents the narrowing of blood vessels and decreases blood pressure.

Formula: C₂₇H₂₉N₅O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 551.62 g/mol

Ref: 3D-BB164259

Bosentan

CAS: 147536-97-8

Endothelin receptor antagonist; vasodilator

Formula: C₂₇H₂₉N₅O₆S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 551.62 g/mol

Ref: 3D-FB19001

Bosentan-13C2, d4

Controlled Product

CAS: 147536-97-8

Formula: C₂C₂₅D₄H₂₅N₅O₆S

Color and Shape: Neat

Molecular weight: 557.624

Ref: TR-B675903