CAS 1476-48-8

p-Hydroxytriamterene sulfate

Description:

p-Hydroxytriamterene sulfate, with the CAS number 1476-48-8, is a chemical compound derived from triamterene, a potassium-sparing diuretic. This substance is characterized by its sulfonic acid group, which enhances its solubility in water compared to its parent compound. It typically appears as a white to off-white crystalline powder. p-Hydroxytriamterene sulfate exhibits properties that make it useful in pharmacology, particularly in the treatment of conditions like hypertension and edema, as it helps to retain potassium while promoting the excretion of sodium and water. The compound's mechanism of action involves inhibition of sodium channels in the distal nephron of the kidney. Additionally, it is important to note that the compound may undergo metabolic processes in the body, leading to various metabolites. Safety and handling precautions are essential, as with any chemical substance, to mitigate potential health risks. Overall, p-Hydroxytriamterene sulfate plays a significant role in medicinal chemistry, particularly in the development of diuretic therapies.

Formula: C₁₂H₁₁N₇O₄S

InChI: InChI=1S/C12H11N7O4S/c13-9-7(5-1-3-6(4-2-5)23-24(20,21)22)16-8-10(14)18-12(15)19-11(8)17-9/h1-4H,(H,20,21,22)(H6,13,14,15,17,18,19)

InChI key: InChIKey=UGLZTFAGJYBEIZ-UHFFFAOYSA-N

SMILES: NC=1C2=C(N=C(N)C(=N2)C3=CC=C(OS(=O)(=O)O)C=C3)N=C(N)N1

Synonyms:

• 4-(2,4,7-Triaminopteridin-6-Yl)-Phenohydrogensulfate(Ester)
• 4-(2,4,7-Triaminopteridin-6-Yl)Phenolhydrogensulfate(Ester)
• 4-(2,4,7-Triaminopteridin-6-Yl)Phenyl Hydrogen Sulfate
• 4-Hydroxy Triamterene Sulfate, Sodium Salt
• Hydroxytriamterene sulfate
• Hydroxytriamterene sulfate ester
• Phenol, 4-(2,4,7-triamino-6-pteridinyl)-, 1-(hydrogen sulfate)
• Phenol, 4-(2,4,7-triamino-6-pteridinyl)-, hydrogen sulfate (ester)
• Phenol, p-(2,4,7-triamino-6-pteridinyl)-, hydrogen sulfate
• Phenol, p-(2,4,7-triamino-6-pteridinyl)-, hydrogen sulfate (ester)
• p-Hydroxytriamterene sulfate

Phenol, 4-(2,4,7-triamino-6-pteridinyl)-, 1-(hydrogen sulfate)

CAS: 1476-48-8

Formula: C₁₂H₁₀N₇NaO₄S

Molecular weight: 371.3071

Ref: IN-DA001F0O

4-Hydroxy Triamterene Sulfate-d4, Sodium Salt

Controlled Product

CAS: 1476-48-8

Applications Isotope labelled 4-hydroxy triamterene sulfate sodium salt a metabolite of Triamterne, a diuretic agent.
References Vollmer, G., et al.: Arzneim.-Forsch., 31, 529 (1981), Gilfrich, H.J., et al.: Eur. J. Clin. Pharmacol., 25, 237 (1983),

Formula: C₁₂H₆D₄N₇NaO₄S

Color and Shape: Neat

Molecular weight: 375.33

Ref: TR-H971072

4-Hydroxy Triamterene Sulfate Potassium Salt

Controlled Product

CAS: 1476-48-8

Formula: C₁₂H₁₁N₇O₄S·K

Color and Shape: Neat

Molecular weight: 388.423

Ref: TR-H971075