CAS 1476-53-5

Novobiocin sodium

Description:

Novobiocin sodium, with the CAS number 1476-53-5, is an antibiotic compound that belongs to the class of coumarin derivatives. It is primarily derived from the bacterium *Streptomyces niveus* and exhibits antibacterial properties, particularly against Gram-positive bacteria. Novobiocin functions by inhibiting bacterial DNA gyrase, an enzyme critical for DNA replication and transcription, thereby disrupting bacterial growth. The sodium salt form enhances its solubility in aqueous solutions, making it suitable for various pharmaceutical applications. In addition to its antibacterial activity, novobiocin has been studied for its potential use in cancer therapy due to its ability to inhibit certain cellular processes. The compound is typically administered in a clinical setting and is subject to specific dosage guidelines due to its pharmacological effects. Safety and efficacy profiles are essential considerations in its use, as with any antibiotic, to prevent resistance development and ensure optimal therapeutic outcomes.

Formula: C₃₁H₃₆N₂O₁₁·Na

InChI: InChI=1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/t23-,25+,26-,29-;/m1./s1

InChI key: InChIKey=BZFOBLOAMAJKQV-RNROJPEYSA-N

SMILES: CC1=C2C(C(O)=C(NC(=O)C3=CC(CC=C(C)C)=C(O)C=C3)C(=O)O2)=CC=C1O[C@H]4[C@H](O)[C@H](OC(N)=O)[C@@H](OC)C(C)(C)O4.[Na]

Synonyms:

• (3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• 5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4H-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate (non-preferred name)
• Albamycin
• Albamycin (capsule)
• Albamycin sodium
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-, sodium salt (1:1)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt
• Cathomycin sodium
• Cathomycin sodium lyovac
• Monosodium novobiocin
• N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide
• NSC 2382
• Novobiocin Sodium
• Novobiocin Sodium Crystalline
• Novobiocin Sodium Usp
• Novobiocin monosodium
• Novobiocin, monosodium salt
• Novobiocin, sodium deriv.
• Sodium albamycin
• Sodium novobiocin
• Vulcamycin
• sodium 7-{[(2R,3R,4S,5R)-4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3-({[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]carbonyl}amino)-8-methyl-2-oxo-2H-chromen-4-olate (non-preferred name)
• Benzamide, N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)-, monosodium salt

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt, 1476-53-5, is an antibiotic compound produced by Streptomyces nieveus which inhibits topoisomerase II. Learn more at Thermo Fisher Scientific.

Formula: C₃₁H₃₅N₂NaO₁₁

Color and Shape: White to pale cream to yellow, Powder

Molecular weight: 634.61

Ref: 02-J60928

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.

Formula: C₃₁H₃₅N₂NaO₁₁

Purity: 99% - 99.28%

Color and Shape: Solid

Molecular weight: 634.61

Ref: TM-T0974

Novobiocin Sodium Salt

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purity: 95%

Color and Shape: Solid

Molecular weight: 634.6062

Ref: IN-DA00AOT3

Novobiocin Sodium

CAS: 1476-53-5

Novobiocin Sodium

Purity: ≥98%

Molecular weight: 634.61g/mol

Ref: 54-BUP11826

Novobiocin sodium salt

CAS: 1476-53-5

Novobiocin sodium salt

Formula: C₃₁H₃₅N₂O₁₁·Na

Purity: By hplc: 96.2% by area (Typical Value in Batch COA)

Color and Shape: off white powder

Molecular weight: 634.60617g/mol

Ref: 54-BIN0394

Novobiocin sodium salt

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purity: ≥ 95.0% (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 634.61

Ref: 7W-GA5711

Novobiocin sodium salt, USP grade

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purity: ≥ 90.0%

Color and Shape: White to off-white powder

Molecular weight: 634.61

Ref: 7W-GP5629

Novobiocin sodium

Controlled Product

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂O₁₁·Na

Color and Shape: Neat

Molecular weight: 634.61

Ref: 04-C15654200

Novobiocin Sodium Salt

Controlled Product

CAS: 1476-53-5

Stability Hygroscopic
Applications Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA.
References Cozarelli, N.R.: Science, 207, 953 (1980); Sumiyoshi, Y. et al.: J. Gen. Virol., 64, 2329 (1983); Lockshon, G. et al.: Nucleic Acids Res., 11, 2999 (1983);

Formula: C₃₁H₃₅N₂O₁₁·Na

Color and Shape: Neat

Molecular weight: 634.61

Ref: TR-N888500

Novobiocin sodium salt, Antibiotic for Culture Media Use Only

CAS: 1476-53-5

Novobiocin sodium salt inhibits bacterial growth by binding to the 50S subunit of the bacterial ribosome, blocking the peptidyl transferase activity required for protein synthesis. The drug binds to DNA sequences containing glucuronic acid, which are essential for peptide bond formation. Novobiocin sodium can be found in pharmaceuticals due to its antimicrobial activity and membrane stability, which makes it suitable for pressuring ionization techniques. It also exhibits less resistance than other antibiotics like triclosan or nalidixic acid because it does not typically bind to the membranes of cells.

Formula: C₃₁H₃₅N₂NaO₁₁

Purity: Min. 90.0 Area-%

Molecular weight: 634.61 g/mol

Ref: 3D-N-9100

Novobiocin sodium

CAS: 1476-53-5

Inhibitor of prokaryotic DNA gyrase, eukaryotic DNA topoisomerase and HSP90

Formula: C₃₁H₃₅N₂NaO₁₁

Purity: Min. 94%

Color and Shape: Powder

Molecular weight: 634.61 g/mol

Ref: 3D-EN15775

Novobiocin Sodium Salt (NVB), 95%

CAS: 1476-53-5

Formula: C₃₁H₃₅N₂NaO₁₁

Purity: min. 95%

Color and Shape: White to pale yellow, Powder, Clear

Molecular weight: 634.61

Ref: SR-27434