CAS 14760-49-7

(11β)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-al

Description:

The chemical substance known as (11β)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-al, with the CAS number 14760-49-7, is a steroid compound that exhibits significant biological activity. It is characterized by the presence of two hydroxyl groups at the 11 and 17 positions, as well as a conjugated diene system and a carbonyl group, which contribute to its reactivity and interaction with biological systems. This compound is part of the pregnane steroid family, which is known for its role in various physiological processes, including hormonal regulation. Its structure suggests potential applications in medicinal chemistry, particularly in the development of therapeutic agents targeting hormonal pathways. The presence of multiple functional groups allows for diverse interactions with biological macromolecules, making it a subject of interest in pharmacological research. Additionally, its unique structural features may influence its solubility, stability, and bioavailability, which are critical factors in drug design and development.

Formula: C₂₁H₂₈O₅

InChI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,11,14-16,18,24,26H,3-8,10H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=JIELFMXLFHFDRT-VWUMJDOOSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)([C@@H](O)C1)[H])[H])(CC[C@@]2(C(C=O)=O)O)[H]

Synonyms:

• (11Beta)-11,17-Dihydroxy-3,20-Dioxopregn-4-En-21-Al
• (11β)-11,17-Dihydroxy-3,20-dioxopregn-4-en-21-al
• 11β,17-Dihydroxy-3,20-dioxopregn-4-en-21-al
• 11β,17-Dihydroxy-4-pregnene-3,20,21-trione
• 4-Pregnen-21-al, 11,17-dihydroxy-3,20-dioxo-
• Cortisol, 21-dehydro-
• Cortisol-21-aldehyde
• Dehydrocortisol
• Nsc 15472
• Pregn-4-en-21-al, 11,17-dihydroxy-3,20-dioxo-, (11beta)-
• Pregn-4-en-21-al, 11,17-dihydroxy-3,20-dioxo-, (11β)-
• Pregn-4-en-21-al, 11β,17-dihydroxy-3,20-dioxo-

Hydrocortisone EP Impurity G (Hydrocortisone-21-Aldehyde)

CAS: 14760-49-7

Formula: C₂₁H₂₈O₅C₂₁H₃₀O₆

Molecular weight: 360.45 378.47

Ref: 4Z-H-103021

Hydrocortisone EP Impurity G

CAS: 14760-49-7

Formula: C₂₁H₂₈O₅

Molecular weight: 360.45

Ref: ST-EA-CP-H9007

Hydrocortisone 21-aldehyde hydrate

Controlled Product

CAS: 14760-49-7

Hydrocortisone 21-aldehyde hydrate (HCA) is an estrogenic substance that can be found in the urine of pregnant women. It is a metabolite of hydrocortisone, as well as a byproduct of estradiol. Hydrocortisone 21-aldehyde hydrate has been shown to inhibit RNA synthesis and bind to DNA, which may be due to its oxidation products. The optimum pH for this compound is 7.6, and it has a low toxicity in the model system used. HCA also reacts with cortisol concentration and carbonyl group content in tissues and animals.

Formula: C₂₁H₃₀O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 378.46 g/mol

Ref: 3D-FH23887

Hydrocortisone Impurity G

Controlled Product

CAS: 14760-49-7

Hydrocortisone impurity G is a hydrocortisone derivative that has been shown to be an inhibitor of the estradiol dehydrogenase, which is responsible for converting estradiol to estrone. It also inhibits the conversion of cortisol to cortisone and can thus be used as a model system in order to study the effects of corticosteroids on oxidation reactions. Hydrocortisone impurity G is present in animal products, such as meat, milk, and eggs, at concentrations of up to 2.5%. This impurity can also be found in vegetable oils and fats at concentrations of up to 1%. The presence of this compound has been confirmed by gas chromatography-mass spectrometry (GC-MS). Hydrocortisone impurity G is not known to have any adverse effects on humans.

Formula: C₂₁H₂₈O₅

Purity: Min. 95%

Molecular weight: 360.4 g/mol

Ref: 3D-PAA76049