CAS 147657-22-5

Calcipotriol monohydrate

Description:

Calcipotriol monohydrate, with the CAS number 147657-22-5, is a synthetic derivative of vitamin D3, primarily used in dermatology for the treatment of psoriasis. It exhibits characteristics typical of a crystalline solid, often appearing as a white to off-white powder. The substance is known for its ability to modulate skin cell proliferation and differentiation, making it effective in reducing the scaling and inflammation associated with psoriasis. Calcipotriol functions as a potent agonist of the vitamin D receptor, influencing various cellular processes. It is soluble in organic solvents but has limited solubility in water, which is a consideration for formulation in topical applications. The monohydrate form indicates the presence of one molecule of water associated with each molecule of calcipotriol, which can affect its stability and solubility. Overall, calcipotriol monohydrate is a crucial therapeutic agent in managing skin conditions, with a well-established safety profile when used as directed.

Formula: C₂₇H₄₀O₃·H₂O

InChI: InChI=1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1

InChI key: InChIKey=XBKHACNRWFKJNC-MANNPBRJSA-N

SMILES: C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](/C=C/[C@@H](O)C4CC4)C)[H])[H].O

Synonyms:

• 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-cyclopropyl-4-hydroxy-1-methyl-2-buten-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, hydrate (1:1), (1R,3S,5Z)-
• 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, monohydrate, (1α,3β,5Z,7E,22E,24S)-
• Calcipotriol monohydrate

CALCIPOTRIOL MONOHYDRATE CRS

CAS: 147657-22-5

CALCIPOTRIOL MONOHYDRATE CRS

Formula: C₂₇H₄₀O₃

Color and Shape: Powder

Molecular weight: 412.6047

Ref: 41-Y0000473

CALCIPOTRIOL MONOHYDRATE

CAS: 147657-22-5

Formula: C₂₇H₄₂O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 430.6200

Ref: IN-DA00ABJ7

Calcipotriol hydrate

CAS: 147657-22-5

Formula: C₂₇H₄₀O₃·xH₂O

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 412.60 (anhydrous)

Ref: 7W-GP2043

Calcipotriol monohydrate

CAS: 147657-22-5

Calcipotriol monohydrate

Purity: ≥98%

Molecular weight: 430.62g/mol

Ref: 54-BUP06700

Calcipotriol Monohydrate

Controlled Product

CAS: 147657-22-5

Applications Calcipotriol Monohydrate is a synthetic derivative of calcitriol, which is a biologically active form of Vitamin D3 (1). Calcipotriol Monohydrate can be used to treat psoriasis (2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Kim, D. H., et al.: Ann Dermatol. 24, 341 (2012) (2) Queille-Roussel, C., et al.: Clin Drug Investig (2016)

Formula: C₂₇H₄₀O₃·H₂O

Color and Shape: Neat

Molecular weight: 430.62

Ref: TR-C144230

Calcipotriol monohydrate - Bio-X ™

CAS: 147657-22-5

Calcipotriol is a synthetic vitamin D2 derivative that is used for the treatment of plaque psoriasis. The exact mechanism of this drug is not well understood but it has shown to be effective in treating patients with bone cancer.

Formula: C₂₇H₄₀O₃•H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 430.62 g/mol

Ref: 3D-BC300055

Calcipotriol monohydrate

CAS: 147657-22-5

Calcipotriol monohydrate, a Vitamin D3 analog, binds well to the vitamin D receptor, used in psoriasis research.

Formula: C₂₇H₄₂O₄

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 430.62

Ref: TM-TQ0244

Calcipotriol monohydrate

CAS: 147657-22-5

Calcipotriol is a synthetic vitamin D3 analog that has been shown to be effective in the treatment of bone cancer. It has a film-forming property and is used in pharmaceutical preparations as well as for wastewater treatment. Calcipotriol monohydrate is made by reacting calcipotriol with hydrochloric acid, which produces an ester bond between the hydroxyl group and the carboxylic acid group. The reaction also produces water, methanol, and methyl ethyl ether. Studies have shown that calcipotriol monohydrate has a chemical stability of over 30 days at room temperature, indicating it can be stored for long periods without degradation.

Formula: C₂₇H₄₀O₃·H₂O

Purity: (%) Min. 96%

Color and Shape: Powder

Molecular weight: 430.62 g/mol

Ref: 3D-FC63561