CAS 147658-54-6

L-Argininamide,L-arginyl-L-arginyl-L-tryptophyl-L-cysteinyl-L-tyrosyl-L-arginyl-L-lysyl-L-cysteinyl-L-tyrosyl-L-lysylglycyl-L-tyrosyl-L-cysteinyl-L-tyrosyl-L-arginyl-L-lysyl-L-cysteinyl-,cyclic (4®17),(8®13)-bis(disulfide)

Description:

L-Argininamide, cyclic (4®17),(8®13)-bis(disulfide) is a complex peptide compound characterized by its unique arrangement of amino acids, including multiple arginine, cysteine, tryptophan, and tyrosine residues. This substance features a cyclic structure formed by disulfide bonds, which contribute to its stability and functional properties. The presence of multiple arginine residues suggests potential roles in biological processes, such as cell signaling and interaction with various biomolecules. The cyclic nature of the compound enhances its resistance to enzymatic degradation, making it of interest in pharmaceutical and biochemical applications. Additionally, the specific arrangement of amino acids may impart unique properties, such as increased solubility or altered binding affinities, which can be crucial for therapeutic efficacy. Overall, this compound exemplifies the complexity and diversity of peptide chemistry, with implications for drug design and development in various biomedical fields.

Formula: C₁₀₉H₁₆₄N₃₈O₂₂S₄

Synonyms:

• TachyplesinI,1-(N2-L-arginyl-L-arginine)-4-L-tyrosine-6-L-lysine-9-L-lysine-11-L-tyrosine-15-L-lysine-
• 15,16,46,47-Tetrathia-2,5,8,11,19,22,25,28,31,34,37,40,43-tridecaazabicyclo[28.14.4]octatetracontane,cyclic peptide deriv.
• 1: PN: WO2009046834 PAGE: 99 claimed protein
• T 22
• T 22(peptide)

(Tyr5·12,Lys7)-Polyphemusin II

CAS: 147658-54-6

T22 peptide, also known as [Tyr5,12,Lys7]-polyphemusin II peptide, is a short, positively charged peptide, analog of polyphemusin peptide which exerts a strong anti- HIV activity. Polyphemusins are known to inhibit the growth of gram-negative bacteria and some fungi such as Candida Albicans. T22 is a potent antagonist of CXCR4 (IC50 = 5.05 nM), a co-receptor used by HIV to penetrate cells.
It has been suggested that T22 exerts its effect against HIV-1 especially by blocking virus-cell fusion and that T22 might interact with HIV envelope protein (such as gp120 ) and T-cell surface protein. T22 antiviral activity has been shown on HIV-infected MT-4 cells with an IC50 of 0.008 µg/mL (2.6 nM). The cytotoxic concentration on HIV virus (CC50) of T22 is 54 µg/mL (17 mM).

Formula: C₁₀₉H₁₆₄N₃₈O₂₂S₄

Purity: Min. 95%

Molecular weight: 2,486.98 g/mol

Ref: 3D-FT108745