CAS 147663-01-2

(-)-9-Hydroxyrisperidone

Description:

(-)-9-Hydroxyrisperidone is a chemical compound that serves as an active metabolite of the antipsychotic medication risperidone. It is characterized by its chiral nature, with the "(-)" designation indicating its specific stereochemistry. This compound exhibits a high affinity for various neurotransmitter receptors, particularly serotonin (5-HT2A) and dopamine (D2) receptors, which are crucial in the modulation of mood and behavior. The presence of a hydroxyl group contributes to its solubility and reactivity, influencing its pharmacokinetic properties. (-)-9-Hydroxyrisperidone is primarily utilized in the treatment of schizophrenia and bipolar disorder, providing therapeutic effects while potentially minimizing side effects associated with its parent compound. Its pharmacological profile includes antipsychotic, anxiolytic, and mood-stabilizing properties. The compound is typically administered in a clinical setting, and its efficacy and safety are monitored through various studies. As with many psychotropic medications, individual responses can vary, necessitating careful dosage and monitoring by healthcare professionals.

Formula: C₂₃H₂₇FN₄O₃

InChI: InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3/t19-/m0/s1

InChI key: InChIKey=PMXMIIMHBWHSKN-IBGZPJMESA-N

SMILES: FC=1C=C2C(C(=NO2)C3CCN(CCC=4C(=O)N5C(=NC4C)[C@@H](O)CCC5)CC3)=CC1

Synonyms:

• R 078544
• 1,2-Benzisoxazole, 4H-pyrido[1,2-a]pyrimidin-4-one deriv.
• (-)-9-Hydroxyrisperidone
• 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-, (9S)-
• (9S)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Risperidone EP Impurity C ((S)-Isomer) ((S)-9-Hydroxy Risperidone, (S)-Paliperidone)

CAS: 147663-01-2

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 426.49

Ref: 4Z-R-0611

Risperidone EP Impurity C ((S)-Isomer)-d4 ((S)-9-Hydroxy Risperidone-d4, (S)-Paliperidone-d4)

CAS: 147663-01-2

Formula: C₂₃H₂₃D₄FN₄O₃

Color and Shape: Pale Yellow Solid

Molecular weight: 430.52

Ref: 4Z-R-0635

(S)-9-Hydroxy Risperidone

Controlled Product

CAS: 147663-01-2

Applications The S-enantiomer metabolite of Risperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),

Formula: C₂₃H₂₇FN₄O₃

Color and Shape: Neat

Molecular weight: 426.48

Ref: TR-H953360

(-)-9-Hydroxyrisperidone

Controlled Product

CAS: 147663-01-2

(-)-9-Hydroxyrisperidone is a metabolite of risperidone that is structurally related to the neurotransmitter dopamine. This compound has been found to be a potent antagonist of serotonin and adrenergic receptors, which may contribute to its therapeutic effects in schizophrenia. (-)-9-Hydroxyrisperidone also has been shown to have a high affinity for human liver plasma proteins, which suggests it may be responsible for the long half-life seen with risperidone. The (+) form of the drug has been shown to be more potent than (-)-9-hydroxyrisperidone, while (-)-9-hydroxyrisperidone is more selective in terms of receptor binding.

Formula: C₂₃H₂₇FN₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 426.48 g/mol

Ref: 3D-IH24118

((S)-9-Hydroxy Risperidone

CAS: 147663-01-2

Formula: C₂₃H₂₇FN₄O₃

Molecular weight: 426.49

Ref: ST-EA-CP-R15070