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CAS 147663-04-5

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7-Hydroxyrisperidone

Description:
7-Hydroxyrisperidone is an active metabolite of the antipsychotic medication risperidone, primarily used in the treatment of schizophrenia and bipolar disorder. It is characterized by its chemical structure, which includes a hydroxyl group (-OH) at the seventh position of the risperidone molecule, contributing to its pharmacological activity. This compound exhibits a high affinity for various neurotransmitter receptors, particularly serotonin (5-HT2A) and dopamine (D2) receptors, which are crucial in modulating mood and behavior. The presence of the hydroxyl group enhances its solubility and bioavailability compared to its parent compound. 7-Hydroxyrisperidone is typically administered in conjunction with risperidone, as it plays a significant role in the drug's overall therapeutic effects and side effect profile. Its pharmacokinetics involve metabolism primarily in the liver, with renal excretion of metabolites. Understanding the characteristics of 7-hydroxyrisperidone is essential for optimizing treatment regimens and managing potential side effects in patients undergoing antipsychotic therapy.
Formula:C23H27FN4O3
InChI:InChI=1S/C23H27FN4O3/c1-14-18(23(30)28-13-17(29)3-5-21(28)25-14)8-11-27-9-6-15(7-10-27)22-19-4-2-16(24)12-20(19)31-26-22/h2,4,12,15,17,29H,3,5-11,13H2,1H3
InChI key:InChIKey=ABWPQNZPAOAQSG-UHFFFAOYSA-N
SMILES:FC=1C=C2C(C(=NO2)C3CCN(CCC=4C(=O)N5C(=NC4C)CCC(O)C5)CC3)=CC1
Synonyms:
  • 1,2-Benzisoxazole, 4H-pyrido[1,2-a]pyrimidin-4-one deriv.
  • 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-7-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
  • 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-7-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
  • 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-7-hydroxy-2-methyl-
  • 7-Hydroxy risperidone-d4
  • 7-Hydroxyrisperidone
  • R 79242
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