CAS 147732-31-8

(R,S)-ortho-Cotinine

Description:

(R,S)-ortho-Cotinine is a chemical compound that belongs to the class of alkaloids, specifically a derivative of nicotine. It is characterized by its chiral nature, possessing two enantiomers, which can exhibit different biological activities. The compound is known for its potential pharmacological effects, including interactions with nicotinic acetylcholine receptors, which may influence neurotransmission and have implications in neuropharmacology. (R,S)-ortho-Cotinine is typically studied for its role in tobacco-related research and its potential therapeutic applications, such as in smoking cessation or neuroprotective strategies. The substance is a colorless to pale yellow liquid or solid, depending on its form, and is soluble in organic solvents. Its molecular structure includes a pyridine ring and a piperidine moiety, contributing to its biological activity. Safety and handling precautions are essential when working with this compound, as with many alkaloids, due to potential toxicity and health effects. Overall, (R,S)-ortho-Cotinine represents a significant area of interest in medicinal chemistry and pharmacology.

Formula: C₁₀H₁₂N₂O

InChI: InChI=1/C10H12N2O/c1-12-9(5-6-10(12)13)8-4-2-3-7-11-8/h2-4,7,9H,5-6H2,1H3

SMILES: CN1C(CCC1=O)c1ccccn1

Synonyms:

• 1-Methyl-5-(Pyridin-2-Yl)Pyrrolidin-2-One

2-Pyrrolidinone, 1-methyl-5-(2-pyridinyl)-

CAS: 147732-31-8

Formula: C₁₀H₁₂N₂O

Color and Shape: Liquid

Molecular weight: 176.2151

Ref: IN-DA001F5S

1-Methyl-5-(pyridin-2-yl)pyrrolidin-2-one

CAS: 147732-31-8

1-Methyl-5-(pyridin-2-yl)pyrrolidin-2-one

Purity: ≥95%

Molecular weight: 176.22g/mol

Ref: 54-OR2505

(+/-)-ortho-Cotinine

Controlled Product

CAS: 147732-31-8

Stability Light Sensitive
Applications A metabolite of Nicotine in humans. Used for internal standardization for routine biomonitoring of nicotine metabolites.
References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)

Formula: C₁₀H₁₂N₂O

Color and Shape: Neat

Molecular weight: 176.22

Ref: TR-C725050