CAS 147762-53-6

Fmoc-O-Phospho-L-tyrosine

Description:

Fmoc-O-Phospho-L-tyrosine is a phosphoamino acid derivative commonly used in peptide synthesis and biochemical research. It features a phenylmethoxycarbonyl (Fmoc) protecting group, which is widely utilized to protect the amino group of amino acids during solid-phase peptide synthesis. The presence of the phosphate group at the hydroxyl position of the tyrosine side chain imparts unique properties, such as increased polarity and the ability to participate in various biochemical interactions, including signaling pathways. This compound is typically soluble in polar solvents, making it suitable for use in aqueous environments. Its structure allows for the incorporation of phosphotyrosine into peptides, facilitating studies on phosphorylation and its effects on protein function. Fmoc-O-Phospho-L-tyrosine is valuable in the development of phosphopeptide libraries and in the investigation of protein-protein interactions, particularly in the context of signal transduction and cellular communication. As with many chemical substances, proper handling and storage conditions are essential to maintain its stability and reactivity.

Formula: C₂₄H₂₂NO₈P

InChI: InChI=1/C24H22NO8P/c26-23(27)22(13-15-9-11-16(12-10-15)33-34(29,30)31)25-24(28)32-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,25,28)(H,26,27)(H2,29,30,31)/t22-/m0/s1

SMILES: c1ccc2c(c1)c1ccccc1C2COC(=N[C@@H](Cc1ccc(cc1)OP(=O)(O)O)C(=O)O)O

Synonyms:

• Fmoc-L-Tyr(Po3-H2)
• Fmoc-L-Tyr(Po3H2)-Oh
• Fmoc-Tyr(H2Po3)-Oh
• Fmoc-Tyrosine(Po3H2)-Oh
• Fmoc-Tyr(Po3H2)-Oh
• N-Alpha-(9-Fluorenylmethyloxycarbonyl)-L-Phosphotyrosine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-phosphono-L-tyrosine
• Fmoc-O-Phospho-Tyr-OH

Fmoc-Tyr(PO₃H₂)-OH

CAS: 147762-53-6

See Ottinger et al. for coupling conditions. Fmoc-phosphotyrosine forms hydrogels upon enzymatic dephosphorylation. Yang and Xu employed this phenomenon to develop a simple visual assay for detecting inhibitors of enzymes.

Formula: C₂₄H₂₂NO₈P

Purity: 98.6%

Color and Shape: White Powder

Molecular weight: 483.41

Ref: 01-4025426

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-phosphono-L-tyrosine

CAS: 147762-53-6

Formula: C₂₄H₂₂NO₈P

Purity: 97%

Color and Shape: Solid

Molecular weight: 483.4071

Ref: IN-DA001F6R

Fmoc-Tyr(H2PO3)-OH

CAS: 147762-53-6

Fmoc-Tyr(H2PO3)-OH

Purity: 98%

Molecular weight: 483.41g/mol

Ref: 54-OR1013397

Fmoc-Tyr(PO3H2)-OH

CAS: 147762-53-6

Molecular weight: 483.41

Ref: 7W-GM9196

Fmoc-O-phospho-L-tyrosine

CAS: 147762-53-6

Fmoc-O-phospho-L-tyrosine is a synthetic compound that belongs to the class of phosphatase inhibitors. It is a potent inhibitor of tyrosine phosphatases, which are enzymes that regulate cellular signaling. Fmoc-O-phospho-L-tyrosine has been shown to inhibit phosphorylation of the insulin receptor and may have an inhibitory effect on other tyrosine kinases. Inhibition of these enzymes results in increased levels of intracellular tyrosine, which can lead to inhibition of protein synthesis and cell proliferation. Fmoc-O-phospho-L-tyrosine has been shown to be effective against growth in cell culture, although more research is needed.

Formula: C₂₄H₂₂NO₈P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 483.41 g/mol

Ref: 3D-FF47781

L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-phosphono-

CAS: 147762-53-6

Purity: 97%

Molecular weight: 483.4129944

Ref: 10-F861853