Isoplumbagin, with the CAS number 14777-17-4, is a naturally occurring naphthoquinone compound primarily derived from certain plant species, particularly those in the genus Plumbago. It exhibits a characteristic yellow to orange color and is known for its potent biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. Isoplumbagin's structure features a naphthalene ring system with two carbonyl groups, which contribute to its reactivity and biological interactions. The compound is soluble in organic solvents but has limited solubility in water, which influences its bioavailability and application in medicinal chemistry. Its mechanism of action often involves the generation of reactive oxygen species and the modulation of various signaling pathways, making it a subject of interest in pharmacological research. Additionally, isoplumbagin's potential therapeutic applications are being explored, although further studies are necessary to fully understand its efficacy and safety in clinical settings.

Isoplumbagin

14777-17-4: Isoplumbagin, with the CAS number 14777-17-4, is a naturally occurring naphthoquinone compound primarily derived from certain plant species, particularly those in the genus Plumbago. It exhibits a characteristic yellow to orange color and is known for its potent biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. Isoplumbagin's structure features a naphthalene ring system with two carbonyl groups, which contribute to its reactivity and biological interactions. The compound is soluble in organic solvents but has limited solubility in water, which influences its bioavailability and application in medicinal chemistry. Its mechanism of action often involves the generation of reactive oxygen species and the modulation of various signaling pathways, making it a subject of interest in pharmacological research. Additionally, isoplumbagin's potential therapeutic applications are being explored, although further studies are necessary to fully understand its efficacy and safety in clinical settings.

<p>8-Hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione is a natural product that has been found to have anticancer activity. It induces apoptosis in human cancer cells and inhibits the growth of bacteria by binding to the 50S ribosomal subunit. 8HMN has also been shown to inhibit the proliferation of cervical cancer cells in vitro. The active form of this compound is acetate extract and it has been shown to have strong anti-inflammatory properties by inhibiting prostaglandin synthesis in neutrophils. 8HMN binds to mitochondrial membrane protein complexes, leading to mitochondrial fission and inhibition of ATP production.</p>

CAS 14777-17-4

Isoplumbagin

8-Hydroxy-2-methyl-1,4-dihydronaphthalene-1,4-dione

Ref: 3D-PAA77717