CAS 147776-06-5

L-161,982

Description:

L-161,982, with the CAS number 147776-06-5, is a synthetic compound primarily recognized for its role as a selective antagonist of the neuropeptide Y (NPY) Y1 receptor. This compound is of interest in pharmacological research, particularly in the context of obesity and metabolic disorders, as NPY is involved in appetite regulation and energy homeostasis. L-161,982 exhibits high affinity and specificity for the Y1 receptor, making it a valuable tool for studying the physiological effects of NPY signaling. In terms of its chemical structure, L-161,982 features a distinct arrangement of functional groups that contribute to its biological activity. The compound is typically characterized by its stability under standard laboratory conditions, although specific handling and storage requirements may apply. As with many pharmacologically active substances, safety data sheets should be consulted for information regarding toxicity and safe handling practices. Overall, L-161,982 represents a significant compound in the exploration of neuropeptide interactions and their implications in health and disease.

Formula: C₃₂H₂₉F₃N₄O₄S₂

InChI: InChI=1/C32H29F3N4O4S2/c1-3-4-13-28-36-39(26-11-7-6-10-25(26)32(33,34)35)31(41)38(28)20-22-14-16-23(17-15-22)24-9-5-8-12-27(24)45(42,43)37-30(40)29-21(2)18-19-44-29/h5-12,14-19H,3-4,13,20H2,1-2H3,(H,37,40)

InChI key: InChIKey=MMDNKTXNUZFVKD-UHFFFAOYSA-N

SMILES: O=C1N(N=C(CCCC)N1CC2=CC=C(C=C2)C3=C(S(NC(=O)C4=C(C)C=CS4)(=O)=O)C=CC=C3)C5=C(C(F)(F)F)C=CC=C5

Synonyms:

• 2-Thiophenecarboxamide, N-[[4′-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1′-biphenyl]-2-yl]sulfonyl]-3-methyl-
• N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]- 2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide
• N-{[4'-({3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,5-dihydro-4H-1,2,4-triazol-4-yl}methyl)biphenyl-2-yl]sulfonyl}-3-methylthiophene-2-carboxamide
• L 161982
• N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide
• L-161,982 >=98% (HPLC)

2-Thiophenecarboxamide, N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-

CAS: 147776-06-5

Formula: C₃₂H₂₉F₃N₄O₄S₂

Purity: 99.04%

Molecular weight: 654.7223

Ref: IN-DA001F6K

L-161982

CAS: 147776-06-5

L-161982

Purity: ≥98%

Molecular weight: 654.72g/mol

Ref: 54-BUP08603

L-161,982

CAS: 147776-06-5

N-{[4'-({3-Butyl-5-Oxo-1-[2-(Trifluoromethyl)Phenyl]-1,5-Dihydro-4H-1,2,4-Triazol-4-Yl}Methyl)-2-Biphenylyl]Sulfonyl}-3-Methyl--2 -Thiophenecarboxamide is a reactive molecule that inhibits the production of prostaglandin E2 (PGE2). It binds to the PGE2 receptor and blocks its activation. N-[{4'-({3-Butyl--5--Oxo-[1-(2-(trifluoromethyl)phenyl]-1,5--dihydro--4H--1,2,4--triazol--4--y l}methyl)-2--biphenylylsulfonyl}] 3methyl 2thiop

Formula: C₃₂H₂₉F₃N₄O₄S₂

Purity: Min. 95%

Molecular weight: 654.72 g/mol

Ref: 3D-FB104037

L-161982

CAS: 147776-06-5

L-161982 is a selective EP4 receptor antagonist that inhibits PGE2-induced ERK phosphorylation and cell proliferation in HCA-7 cells.Cost-effective and quality-assured.

Formula: C₃₂H₂₉F₃N₄O₄S₂

Purity: 99.58% - 99.6%

Color and Shape: Solid

Molecular weight: 654.72

Ref: TM-T15681