CAS 147794-23-8

omega-conotoxin mviic

Description:

Omega-conotoxin MVIIA is a peptide derived from the venom of the Conus snail, specifically Conus magus. It is a potent and selective blocker of N-type voltage-gated calcium channels (VGCCs), which play a crucial role in neurotransmitter release and pain signaling. This characteristic makes omega-conotoxin MVIIA of significant interest in pharmacology, particularly for its potential applications in pain management and neurological research. The peptide consists of a specific sequence of amino acids that contributes to its unique structure and function. It exhibits high affinity for the N-type calcium channels, inhibiting calcium influx and thereby reducing neurotransmitter release, which can alleviate pain. Omega-conotoxin MVIIA is also studied for its potential therapeutic effects in various neurological disorders. Due to its origin from marine organisms, it represents a fascinating example of how natural products can lead to the development of novel pharmacological agents. Its stability and specificity make it a valuable tool in both research and potential clinical applications.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Synonyms:

• w-Conotoxin MVIIC, Conus magus
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/ Cys15 and Cys26)
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2 (Disulfide Bridge: 1-16, 8-20, And 15-26)
• Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-Nh2
• Ckgkgapcrktmydccsgscgrrgkc-Nh2 (Disulfide Bridge: 1-16,8-20 And 15-26)
• Omega-Cgtx Mviic
• Omega-Conotoxin Mviic, Conus Magus

ω-Conotoxin MVIIC

CAS: 147794-23-8

Like ω-conotoxin GVIA, this Conus magus peptide inhibits presynaptic Ca²⁺ channels. However, ω-conotoxin MVIIC clearly inhibits additional Ca²⁺ channel subtypes in the mammalian central nervous system. Thus, it should become a standard pharmacological reagent for investigating synaptic transmission in the mammalian nervous system.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purity: > 98%

Color and Shape: White Powder

Molecular weight: 2749.29

Ref: 01-4030522

ω-Conotoxin MVIIC

CAS: 147794-23-8

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purity: 98%

Color and Shape: White Lyophilised Solid

Molecular weight: 2749

Ref: TM-TP2064

ω-Conotoxin MVIIC

CAS: 147794-23-8

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Molecular weight: 2749.25

Ref: 7W-GK3612

Omega-Conotoxin MVIIC

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide that binds to the nicotinic acetylcholine receptor and activates it, leading to inhibition of neurotransmitter release. It is used as a research tool for studying the pharmacology of ion channels and their ligands. Omega-Conotoxin MVIIC is purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons. CONOTOXINS are small peptides that bind to the nicotinic acetylcholine receptor and activate it, leading to inhibition of neurotransmitter release. They are used as research tools for studying the pharmacology of ion channels and their ligands. CONOTOXINS are purified from Conus magus venom. The peptide has been shown to be an inhibitor of potassium channels in rat cortical neurons.END> END>

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purity: Min. 95%

Molecular weight: 2,749.3 g/mol

Ref: 3D-PCN-4283-S

ω-Conotoxin MVIIC

CAS: 147794-23-8

Omega-conotoxins are a group of peptides found in the venom of predatory marine snails. Omega-conotoxin MVIIC is a potent inhibitor of nicotinic acetylcholine receptors. It blocks the activation and desensitization of nicotinic acetylcholine receptor channels and has been used as a research tool to study the function of these proteins. Omega-conotoxin MVIIC binds to its target by interacting with specific sites on the alpha subunit of nicotinic acetylcholine receptor channels, which leads to inhibition of voltage-gated calcium channels. The high purity and low endotoxin levels make this product suitable for life science research applications.

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purity: Min. 95%

Molecular weight: 2,749.3 g/mol

Ref: 3D-PCN-4283-V

Omega-Conotoxin MVIIC

Controlled Product

CAS: 147794-23-8

Omega-Conotoxin MVIIC is a peptide toxin that blocks the voltage-dependent calcium channels. It has been shown to have neuroprotective properties and to inhibit glutamate induced neurotoxicity in vitro and in vivo. Omega-Conotoxin MVIIC inhibits neurotransmitter release by blocking the calcium channels and thereby reduces oxidative stress, which prevents neuronal cell death. This toxin also blocks the activity of voltage-dependent sodium channels, but its effects are not as potent as those on calcium channels. Omega-Conotoxin MVIIC has been found to be effective against cerebellar granule neurons, as well as other neurons in the brainstem, cerebellum, hippocampus, and cerebral cortex. The molecular weight of this toxin is approximately 10 kDa and it contains subunits (a total of eight).

Formula: C₁₀₆H₁₇₈N₄₀O₃₂S₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 2,749.26 g/mol

Ref: 3D-FC110353