CAS 147819-32-7

IGF-I Analog

Description:

IGF-I Analog, with the CAS number 147819-32-7, is a synthetic peptide that mimics the action of Insulin-like Growth Factor I (IGF-I), a hormone crucial for growth and development. This analog is designed to enhance the biological activity of IGF-I, promoting cell growth, differentiation, and survival. It typically exhibits a higher affinity for IGF receptors compared to natural IGF-I, which can lead to increased anabolic effects in various tissues, including muscle and bone. The substance is often studied for its potential therapeutic applications in conditions such as growth deficiencies, muscle wasting, and age-related decline in IGF levels. Characteristically, IGF-I Analog is soluble in aqueous solutions and may have specific stability and storage requirements to maintain its efficacy. Its pharmacokinetics can vary based on formulation and administration route, influencing its therapeutic potential. As with any peptide, careful consideration of dosage and potential side effects is essential in clinical applications.

Formula: C₅₅H₈₈N₁₄O₁₅S₂

InChI: InChI=1/C55H88N14O15S2/c1-27(2)24-35(65-50(79)39-17-12-22-68(39)51(80)31(6)61-43(72)29(4)59-47(76)36(66-42(71)28(3)58)25-54-18-19-55(84)41(86-55)40(54)85-54)46(75)64-34(15-9-11-21-57)52(81)69-23-13-16-38(69)49(78)60-30(5)44(73)63-33(14-8-10-20-56)45(74)67-37(26-70)48(77)62-32(7)53(82)83/h18-19,26-41,84H,8-17,20-25,56-58H2,1-7H3,(H,59,76)(H,60,78)(H,61,72)(H,62,77)(H,63,73)(H,64,75)(H,65,79)(H,66,71)(H,67,74)(H,82,83)/t28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40?,41?,54?,55?/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=N[C@@H](C)C(=N[C@@H](CCCCN)C(=N[C@@H](C=O)C(=N[C@@H](C)C(=O)O)O)O)O)O)O)N=C([C@@H]1CCCN1C(=O)[C@H](C)N=C([C@H](C)N=C([C@H](CC12C=CC3(C(C1S2)S3)O)N=C([C@H](C)N)O)O)O)O

Synonyms:

• H-Cys-Tyr-Ala-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Cys-OH (Disulfide bond)
• L-alanyl-3-(7-hydroxy-3,8-dithiatricyclo[5.1.0.02,4]oct-5-en-4-yl)-L-alanyl-L-alanyl-L-alanyl-L-prolyl-L-leucyl-L-lysyl-L-prolyl-L-alanyl-L-lysyl-3-oxo-L-alanyl-L-alanine
• H-Cys-Tyr-Ala-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Cys-Oh

IGF-I Analog

CAS: 147819-32-7

The IGF-I peptide analog JB-1 was able to inhibit the autophosphorylation of the IGF-I receptor by IGF-I as well as the growth of several different cell types, including prostate carcinoma cells and SV40-transformed cells. IGF1 analogs as JB-1 might be useful in treating abnormal cell growth.

Formula: C₅₅H₈₈N₁₄O₁₅S₂

Purity: 95.1%

Color and Shape: White Lyophilisate

Molecular weight: 1249.52

Ref: 01-4018631

H-1356

CAS: 147819-32-7

H-1356 is an insulin-like growth factor 1(IGF-I) analog that inhibits autophosphorylation of IGF-I receptor.

Formula: C₅₅H₈₈N₁₄O₁₅S₂

Color and Shape: Solid

Molecular weight: 1249.5

Ref: TM-T70568

IGF-I Analog

CAS: 147819-32-7

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Formula: C₅₅H₈₈N₁₄O₁₅S₂

Purity: Min. 95%

Molecular weight: 1,249.5 g/mol

Ref: 3D-FI108420