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CAS 147900-24-1

:

19,19-difluoroandrost-4-ene-3,6,17-trione

Description:
19,19-Difluoroandrost-4-ene-3,6,17-trione, with the CAS number 147900-24-1, is a synthetic steroid derivative characterized by the presence of two fluorine atoms at the 19-position of the androstane backbone. This compound features a trione functional group, indicating the presence of three carbonyl (C=O) groups located at the 3, 6, and 17 positions, which significantly influences its reactivity and biological activity. The fluorination at the 19-position can enhance the compound's metabolic stability and alter its interaction with biological targets, potentially affecting its pharmacological properties. As a steroid, it may exhibit hormonal activity, influencing various physiological processes. The structural modifications, including the presence of the double bond at the 4-position, contribute to its unique characteristics compared to other steroids. Due to its specific functional groups and structural features, 19,19-difluoroandrost-4-ene-3,6,17-trione is of interest in medicinal chemistry and may have applications in the development of therapeutic agents.
Formula:C19H22F2O3
InChI:InChI=1/C19H22F2O3/c1-18-6-5-13-11(12(18)2-3-16(18)24)9-15(23)14-8-10(22)4-7-19(13,14)17(20)21/h8,11-13,17H,2-7,9H2,1H3/t11-,12-,13-,18-,19-/m0/s1
SMILES:C[C@]12CC[C@H]3[C@@H](CC(=O)C4=CC(=O)CC[C@]34C(F)F)[C@@H]1CCC2=O
Synonyms:
  • 19,19-Difluoro-AT
  • Androst-4-ene-3,6,17-trione-19,19-difluoro-
  • 19,19-Difluoroandrost-4-ene-3,6,17-trione
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Found 2 products.
  • Androst-4-ene-3,6,17-trione, 19,19-difluoro- (9CI)
    Indagoo
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    Androst-4-ene-3,6,17-trione, 19,19-difluoro- (9CI)

    CAS:
    Formula:C19H22F2O3
    Molecular weight:336.373

    Ref: IN-DA001FA1

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  • 19,19-Difluoroandrost-4-Ene-3,6,17-Trione
    Biosynth
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    19,19-Difluoroandrost-4-Ene-3,6,17-Trione

    Controlled Product
    CAS:
    19,19-Difluoroandrost-4-ene-3,6,17-trione is a steroid that inhibits aromatase activity. It has been shown to inhibit the production of estrogen in human placental cells. The inhibition constant for this compound is 0.69 μM. Rate constants for the inhibition of aromatase activity in human placental cells are 0.0014/min and 0.0011/min at concentrations of 0.1 and 1 μM respectively. This compound is biphasic with an inactivation half-life of 8 min at a concentration of 10 μM and a time dependent inhibition constant of 11 min at a concentration of 10 μM. 19,19-Difluoroandrost-4-ene-3,6,17-trione is a competitive inhibitor that binds to the heme moiety on the enzyme's active site and prevents substrate binding by sterically blocking access to it. This drug also has
    Formula:C19H22F2O3
    Purity:Min. 95%
    Molecular weight:336.37 g/mol

    Ref: 3D-FD86358

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