CAS 148-82-3

Melphalan

Description:

Melphalan, with the CAS number 148-82-3, is a synthetic alkylating agent primarily used in chemotherapy for treating certain types of cancers, particularly multiple myeloma and ovarian cancer. It is a derivative of nitrogen mustard and functions by interfering with DNA replication, leading to cell death, particularly in rapidly dividing cancer cells. Melphalan is typically administered intravenously or orally and is known for its ability to cross the blood-brain barrier, which can be advantageous in treating central nervous system malignancies. The compound is characterized by its relatively low solubility in water and is often formulated with stabilizers to enhance its stability and efficacy. Common side effects associated with melphalan treatment include myelosuppression, gastrointestinal disturbances, and potential long-term risks such as secondary malignancies. Due to its potent effects and potential toxicity, melphalan is usually prescribed under strict medical supervision, with careful monitoring of blood counts and overall patient health during treatment.

Formula: C₁₃H₁₈Cl₂N₂O₂

InChI: InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1

InChI key: InChIKey=SGDBTWWWUNNDEQ-LBPRGKRZSA-N

SMILES: N(CCCl)(CCCl)C1=CC=C(C[C@@H](C(O)=O)N)C=C1

Synonyms:

• 3-[p-bis(2-Chloroethyl)amino]phenylalanine, L-
• 3025Cb
• 4-[Bis(2-chloroethyl)amino]-<span class="text-smallcaps">L</span>-phenylalanine
• 67: PN: WO2010011890 PAGE: 37 claimed protein
• <span class="text-smallcaps">L</span>-PAM
• <span class="text-smallcaps">L</span>-Phenylalanine mustard
• <span class="text-smallcaps">L</span>-Phenylalanine mustard hydrochloride
• <span class="text-smallcaps">L</span>-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
• <span class="text-smallcaps">L</span>-Sarcolysin
• <span class="text-smallcaps">L</span>-Sarcolysine
• <span class="text-smallcaps">L</span>-Sarkolysin
• Alanine nitrogen mustard
• Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, <span class="text-smallcaps">L</span>-
• Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, L-
• Alkeran
• Cb 3025
• L-Pam
• L-Phenylalanine mustard
• L-Phenylalanine mustard hydrochloride
• L-Sarcolysin
• L-Sarcolysine
• L-Sarkolysin
• Levofalan
• Levofolan
• Levopholan
• Melfalan
• Melfalano
• Melphalan
• Nsc 241286
• Nsc 8806
• Phenylalanine mustard
• Sarcoclorin
• 4-[bis(2-chloroethyl)amino]-l-phenylalanine
• Melphalan HCl
• Melphalan 2HCl
• 4-[Bis(2-chloroethyl)amino]-L-phenylalanine
• 4-[bis(2-chloroethyl)amino]phenylalanine
• L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
• 2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid

MELPHALAN FOR SYSTEM SUITABILITY CRS

CAS: 148-82-3

MELPHALAN FOR SYSTEM SUITABILITY CRS

Formula: C₁₃H₁₈Cl₂N₂O₂

Color and Shape: Powder

Molecular weight: 305.2002

Ref: 41-Y0001457

Melphalan

CAS: 148-82-3

Melphalan

Formula: C₁₃H₁₈Cl₂N₂O₂

Purity: 91.3%

Color and Shape: Light Brown Solid

Molecular weight: 304.07453

Ref: 47-391

Melphalan

CAS: 148-82-3

Melphalan is an alkylating agent. It has been used in combination with the HDAC inhibitor as a drug for the treatment of multiple myeloma (MM) cell lines and as a chemotherapy agent for breast cancer cell lines.

Formula: C₁₃H₁₈Cl₂N₂O₂

Molecular weight: 305.21

Ref: TM-T60710

Melphalan

CAS: 148-82-3

Formula: C₁₃H₁₈Cl₂N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 305.20

Ref: 4Z-M-854

Melphalan Impurity 20

CAS: 148-82-3

Formula: C₁₃H₂₀N₂O₄

Molecular weight: 268.31

Ref: 4Z-M-8540

Melphalan, USP grade

CAS: 148-82-3

Formula: C₁₃H₁₈Cl₂N₂O₂

Purity: 94.0 - 100.5 % (dried, ionisable chlorine-free basis)

Color and Shape: White to almost white powder

Molecular weight: 305.20

Ref: 7W-GP3789

Melphalan

CAS: 148-82-3

Formula: C₁₃H₁₈Cl₂N₂O₂

Purity: ≥ 95.0%

Color and Shape: White, off-white or pale yellow powder

Molecular weight: 305.20

Ref: 7W-GP0943

Melphalan

Controlled Product

CAS: 148-82-3

Applications Melphalan is an antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),

Formula: C₁₃H₁₈Cl₂N₂O₂

Color and Shape: Neat

Molecular weight: 305.20

Ref: TR-M216900

Melphalan

CAS: 148-82-3

Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agent

Formula: C₁₃H₁₈Cl₂N₂O₂

Purity: (Titration) 93.0 To 100.5%

Color and Shape: White Off-White Powder

Molecular weight: 305.2 g/mol

Ref: 3D-FB25047