CAS 148-82-3: Melphalan
Description:Melphalan, with the CAS number 148-82-3, is a synthetic alkylating agent primarily used in chemotherapy for treating certain types of cancers, particularly multiple myeloma and ovarian cancer. It is a derivative of nitrogen mustard and functions by interfering with DNA replication, leading to cell death, particularly in rapidly dividing cancer cells. Melphalan is typically administered intravenously or orally and is known for its ability to cross the blood-brain barrier, which can be advantageous in treating central nervous system malignancies. The compound is characterized by its relatively low solubility in water and is often formulated with stabilizers to enhance its stability and efficacy. Common side effects associated with melphalan treatment include myelosuppression, gastrointestinal disturbances, and potential long-term risks such as secondary malignancies. Due to its potent effects and potential toxicity, melphalan is usually prescribed under strict medical supervision, with careful monitoring of blood counts and overall patient health during treatment.
Formula:C13H18Cl2N2O2
InChI:InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
InChI key:InChIKey=SGDBTWWWUNNDEQ-LBPRGKRZSA-N
SMILES:O=C(O)C(N)CC1=CC=C(C=C1)N(CCCl)CCCl
- Synonyms:
- 3-[p-bis(2-Chloroethyl)amino]phenylalanine, L-
- 3025Cb
- 4-[Bis(2-chloroethyl)amino]-<span class="text-smallcaps">L</span>-phenylalanine
- 67: PN: WO2010011890 PAGE: 37 claimed protein
- <span class="text-smallcaps">L</span>-PAM
- <span class="text-smallcaps">L</span>-Phenylalanine mustard
- <span class="text-smallcaps">L</span>-Phenylalanine mustard hydrochloride
- <span class="text-smallcaps">L</span>-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
- <span class="text-smallcaps">L</span>-Sarcolysin
- <span class="text-smallcaps">L</span>-Sarcolysine
- See more synonyms
- <span class="text-smallcaps">L</span>-Sarkolysin
- Alanine nitrogen mustard
- Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, <span class="text-smallcaps">L</span>-
- Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, L-
- Alkeran
- Cb 3025
- L-Pam
- L-Phenylalanine mustard
- L-Phenylalanine mustard hydrochloride
- L-Sarcolysin
- L-Sarcolysine
- L-Sarkolysin
- Levofalan
- Levofolan
- Levopholan
- Melfalan
- Melfalano
- Melphalan
- Nsc 241286
- Nsc 8806
- Phenylalanine mustard
- Sarcoclorin
- 4-[bis(2-chloroethyl)amino]-l-phenylalanine
- Melphalan HCl
- Melphalan 2HCl
- 4-[Bis(2-chloroethyl)amino]-L-phenylalanine
- 4-[bis(2-chloroethyl)amino]phenylalanine
- L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-
- 2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
- 3-(4-bis(2-chloroethyl)aminophenyl)-L-alanine
