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CAS 148093-65-6

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defensin hnp-1 human

Description:
Defensin HNP-1 (Human Neutrophil Peptide 1) is a member of the defensin family, which are small cationic peptides known for their antimicrobial properties. It is primarily produced by neutrophils and plays a crucial role in the innate immune response. HNP-1 exhibits broad-spectrum antimicrobial activity against bacteria, fungi, and some viruses, functioning by disrupting microbial membranes. Structurally, it is characterized by a compact, globular shape stabilized by three disulfide bonds, which contribute to its stability and function. The peptide is positively charged, which enhances its interaction with negatively charged microbial membranes. In addition to its antimicrobial functions, HNP-1 is involved in modulating immune responses, including chemotaxis and inflammation. Its role in host defense makes it a subject of interest in research related to infectious diseases and potential therapeutic applications. The CAS number 148093-65-6 uniquely identifies this peptide in chemical databases, facilitating its study and application in various scientific fields.
Formula:C150H222N44O38S6
Synonyms:
  • H-Ala-Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys-OH (Disulfide bonds between Cys2 and Cys30/Cys4 and Cys19/ Cys9 and Cys29)
  • L-Cysteine,L-alanyl-L-cysteinyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-prolyl-L-alanyl-L-cysteinyl-L-isoleucyl-L-alanylglycyl-L-a-glutamyl-L-arginyl-L-arginyl-L-tyrosylglycyl-L-threonyl-L-cysteinyl-L-isoleucyl-L-tyrosyl-L-glutaminylglycyl-L-arginyl
  • DefensinNP 1 (human)
  • 1: PN: US20060057654 SEQID: 1 claimed protein
  • Defensin HNP 1
  • Hnp 1
  • Human neutrophil peptide 1
  • NP 1 (human)
  • Defensin HNP-1 (human)
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