CAS 148408-66-6
:docetaxel trihydrate
Description:
Docetaxel trihydrate is a semi-synthetic chemotherapeutic agent derived from the yew tree, specifically from the compound paclitaxel. It is primarily used in the treatment of various cancers, including breast, lung, and prostate cancers. The substance is characterized by its ability to inhibit cell division by stabilizing microtubules, thereby preventing the normal breakdown of the mitotic spindle during cell division. Docetaxel trihydrate is typically administered intravenously and is known for its effectiveness in promoting apoptosis in cancer cells. In terms of physical properties, it appears as a white to off-white crystalline powder, and its trihydrate form indicates the presence of three water molecules associated with each molecule of docetaxel. The compound is soluble in organic solvents like ethanol and dimethyl sulfoxide but has limited solubility in water. Its pharmacokinetics involve extensive metabolism in the liver, primarily through cytochrome P450 enzymes, and it is excreted mainly via the bile. As with many chemotherapeutic agents, docetaxel trihydrate can have significant side effects, including neutropenia, fatigue, and gastrointestinal disturbances.
Formula:C43H53NO14·3H2O
InChI:InChI=1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+;;;/m0.../s1
InChI key:InChIKey=XCDIRYDKECHIPE-QHEQPUDQSA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H].O
Synonyms:- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (betaS)-, hydrate (1:3)
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, hydrate (1:3), (αR,βS)-
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, trihydrate, (αR,βS)-
- Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester trihydrate, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- Docetaxel・Trihydrate
- Taxespira
- Docetaxel.Trihydrate
- Docetaxel trihydrate
- Docetaxel(Trihydrate)
- See more synonyms
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Found 12 products.
DOCETAXEL TRIHYDRATE CRS
CAS:<p>DOCETAXEL TRIHYDRATE CRS</p>Formula:C43H53NO14Color and Shape:Crystalline Powder. White. Powder.Molecular weight:807.8792Docetaxel ((2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate trihydrate)
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFormula:C43H53NO14·3H2OColor and Shape:White PowderMolecular weight:807.34661Docetaxel Trihydrate
CAS:Controlled ProductFormula:C43H53NO14H2OColor and Shape:NeatMolecular weight:861.93Docetaxel Crotonaldehyde Analog
CAS:Controlled ProductFormula:C43H51NO14Color and Shape:NeatMolecular weight:805.86Docetaxel-d5
CAS:Controlled Product<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>Formula:C43D5H48NO14Color and Shape:NeatMolecular weight:812.91Docetaxel trihydrate
CAS:<p>A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.</p>Formula:C43H53NO14•(H2O)3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:861.93 g/molDocetaxel trihydrate - Bio-X ™
CAS:<p>Docetaxel is a cytotoxic semi-synthetic taxane and is an anthracycline antibiotic. The compound is an anti-microtubule agent and has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.<br>Docetaxel trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C43H53NO14•(H2O)3Purity:Min. 90 Area-%Molecular weight:861.93 g/molDocetaxel trihydrate
CAS:<p>Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis.</p>Formula:C43H59NO17Purity:98.68% - >99.99%Color and Shape:White Crystalline PowderMolecular weight:861.95
