CAS 1485081-57-9

Belinostat Amide

Description:

Belinostat amide is a synthetic compound primarily recognized for its role as a histone deacetylase (HDAC) inhibitor, which is significant in cancer therapy. It is derived from belinostat, a drug approved for the treatment of peripheral T-cell lymphoma. The compound exhibits a mechanism of action that involves the modulation of gene expression through the inhibition of HDAC enzymes, leading to an accumulation of acetylated histones and altered chromatin structure. This alteration can induce cell cycle arrest, differentiation, and apoptosis in cancer cells. Belinostat amide is characterized by its specific molecular structure, which includes functional groups that contribute to its biological activity. It is typically studied in the context of various malignancies and is of interest in ongoing research for its potential therapeutic applications. Safety and efficacy profiles are evaluated in clinical settings, and like many HDAC inhibitors, it may have side effects that require monitoring during treatment. Overall, belinostat amide represents a promising avenue in the field of oncology and epigenetic therapy.

Formula: C₁₅H₁₄N₂O₃S

Synonyms:

• Belinostat Impurity 4 (Belinostat Amide)
• (2E)-3-[3-[(Phenylamino)sulfonyl]phenyl]-2-propenamide
• Belinostat Amide
• Belinostat Amide Impurity
• Belinostat Impurity 2
• Belinostat M2
• 2-Propenamide, 3-[3-[(phenylamino)sulfonyl]phenyl]-, (2E)-

Belinostat Amide

CAS: 1485081-57-9

Formula: C₁₅H₁₄N₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 302.35

Ref: 4Z-B-130005

Belinostat Amide-d5

CAS: 1485081-57-9

Formula: C₁₅H₉D₅N₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 307.38

Ref: 4Z-B-130006

Belinostat Amide

Controlled Product

CAS: 1485081-57-9

Formula: C₁₅H₁₄N₂O₃S

Color and Shape: Neat

Molecular weight: 302.35

Ref: TR-B131480

Belinostat Amide-d5

Controlled Product

CAS: 1485081-57-9

Formula: C₁₅D₅H₉N₂O₃S

Color and Shape: Neat

Molecular weight: 307.379

Ref: TR-B131482

Belinostat amide

CAS: 1485081-57-9

Belinostat amide is an inhibitor of the histone deacetylase HDAC6, which is a protein that regulates gene expression. Belinostat amide is a peptidomimetic that can be used as a research tool to investigate the role of HDAC6 in cellular processes such as DNA replication and protein synthesis. Belinostat amide binds to the receptor site of HDAC6 and inhibits its function by blocking the enzyme's catalytic activity. It has been shown to inhibit ion channels and antibody production, as well as activate some receptors.

Formula: C₁₅H₁₄N₂O₃S

Purity: Min. 95%

Molecular weight: 302.40 g/mol

Ref: 3D-KJC08157

Belinostat Amide

CAS: 1485081-57-9

Formula: C₁₅H₁₄N₂O₃S

Molecular weight: 302.35

Ref: ST-EA-CP-B87002