CAS 148553-51-9

(R)-Pregabalin

Description:

(R)-Pregabalin is a pharmaceutical compound primarily used as an anticonvulsant and analgesic. It is a chiral molecule, with the (R) configuration being the active enantiomer that exhibits therapeutic effects. The substance is a derivative of gamma-aminobutyric acid (GABA) and functions by modulating calcium channel activity, which in turn reduces the release of excitatory neurotransmitters. This mechanism contributes to its efficacy in treating neuropathic pain, epilepsy, and generalized anxiety disorder. (R)-Pregabalin is typically administered in oral form and is known for its relatively high bioavailability. The compound is characterized by its solubility in water and organic solvents, which facilitates its formulation in various pharmaceutical preparations. Its safety profile is generally favorable, although side effects can include dizziness, somnolence, and peripheral edema. As a controlled substance in many jurisdictions, (R)-Pregabalin is subject to regulations to prevent misuse and ensure proper medical use.

Formula: C₈H₁₇NO₂

InChI: InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m1/s1

InChI key: InChIKey=AYXYPKUFHZROOJ-SSDOTTSWSA-N

SMILES: [C@@H](CC(C)C)(CC(O)=O)CN

Synonyms:

• (3R)-3-(Aminomethyl)-5-methylhexanoic acid
• (R)-3-(Aminomethyl)-5-methylhexanoic acid
• (R)-Pregabalin
• Hexanoic acid, 3-(aminomethyl)-5-methyl-, (R)-
• Hexanoicacid, 3-(aminomethyl)-5-methyl-, (R)-
• Pd 144550
• ent-Pregabalin
• Hexanoic acid, 3-(aminomethyl)-5-methyl-, (3R)-

PREGABALIN IMPURITY B CRS

CAS: 148553-51-9

PREGABALIN IMPURITY B CRS

Ref: 41-Y0001807

Pregabalin Related Compound A ((R)-3-(Aminomethyl)-5-methylhexanoic acid)

CAS: 148553-51-9

Amino-acids and their esters other than those containing more than one kind of oxygen function, excluding aromatic amino-acids, nesoi

Formula: C₈H₁₇NO₂

Color and Shape: White Crystalline Powder

Molecular weight: 159.12593

Ref: 45-1559629

Pregabalin EP Impurity B (Pregabalin USP Related Compound A, (R)-Pregabalin)

CAS: 148553-51-9

Formula: C₈H₁₇NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 159.23

Ref: 4Z-P-277

(R)-Pregabalin

Controlled Product

CAS: 148553-51-9

Formula: C₈H₁₇NO₂

Color and Shape: Neat

Molecular weight: 159.23

Ref: 86-MM1376.02

(R)-Pregabalin

Controlled Product

CAS: 148553-51-9

Impurity Pregabalin USP Related Compound A
Applications R-Enantiomer of Pregabalin. A GABA analogue used as an anticonvulsant. Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia (less potent than the S-Enantiomer). Pregabalin USP Related Compound A.
References Field, M.J. et al.: Br. J. Pharmacol., 132, 1 (2001); Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993);

Formula: C₈H₁₇NO₂

Color and Shape: White

Molecular weight: 159.23

Ref: TR-P704785

Pregabalin EP Impurity B

CAS: 148553-51-9

Formula: C₈H₁₇NO₂

Molecular weight: 159.23

Ref: ST-EA-CP-P29002

Pregabalin USP related compound A

Controlled Product

CAS: 148553-51-9

R-Enantiomer of Pregabalin

Formula: C₈H₁₇NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 159.23 g/mol

Ref: 3D-FP27138