CAS 148564-47-0

Milfasartan

Description:

Milfasartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which function by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby lowering blood pressure. The chemical formula of Milfasartan reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. It is characterized by its high selectivity for the angiotensin II receptor subtype 1 (AT1), which enhances its efficacy in managing blood pressure. Milfasartan is typically administered orally and is known for its favorable pharmacokinetic profile, including good bioavailability and a relatively long half-life, allowing for once-daily dosing. Additionally, it may exhibit beneficial effects on renal function and cardiovascular health. As with other medications in its class, potential side effects can include dizziness, fatigue, and elevated potassium levels, necessitating monitoring during treatment.

Formula: C₃₀H₃₀N₆O₃S

InChI: InChI=1/C30H30N6O3S/c1-4-5-10-26-25(29(37)36(19(2)31-26)18-27-24(15-16-40-27)30(38)39-3)17-20-11-13-21(14-12-20)22-8-6-7-9-23(22)28-32-34-35-33-28/h6-9,11-16H,4-5,10,17-18H2,1-3H3,(H,32,33,34,35)

SMILES: CCCCc1c(Cc2ccc(cc2)c2ccccc2c2n[nH]nn2)c(=O)n(Cc2c(ccs2)C(=O)OC)c(C)n1

Synonyms:

• Milfasartan [INN]
• Methyl 2-((4-butyl-2-methyl-6-oxo-5-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-1(6H)-pyrimidinyl)methyl)-3-thiophenecarboxylate
• Unii-8Ual5421Cl
• methyl 2-{[4-butyl-2-methyl-6-oxo-5-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}pyrimidin-1(6H)-yl]methyl}thiophene-3-carboxylate

Milfasartan

CAS: 148564-47-0

Formula: C₃₀H₃₀N₆O₃S

Molecular weight: 554.6626

Ref: IN-DA001L09

Milfasartan

CAS: 148564-47-0

Milfasartan is an angiotensin II receptor blocker (ARB), which is synthetically derived. Its mode of action involves selectively blocking the binding of angiotensin II to the angiotensin I receptor, a crucial aspect in the regulation of blood pressure. This inhibition results in vasodilation, thereby reducing blood pressure and decreasing the workload on the heart.

Formula: C₃₀H₃₀N₆O₃S

Purity: Min. 95%

Molecular weight: 554.7 g/mol

Ref: 3D-YFA56447

Milfasartan

CAS: 148564-47-0

Milfasartan: Potent AT1 antagonist, oral, effectively reduces blood pressure in hypertensive rats.

Formula: C₃₀H₃₀N₆O₃S

Color and Shape: Solid

Molecular weight: 554.66

Ref: TM-T28039