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CAS 148717-90-2

:

squalamine

Description:
Squalamine is a naturally occurring aminosterol, primarily derived from the liver of the dogfish shark (Squalus acanthias). It is characterized by its unique structure, which includes a steroid backbone with multiple amine groups, contributing to its amphipathic properties. This amphipathicity allows squalamine to interact with both lipid and aqueous environments, making it a potential candidate for various biomedical applications. Squalamine exhibits broad-spectrum antimicrobial activity, effective against bacteria, fungi, and certain viruses, which has garnered interest in its use as an antiviral and antifungal agent. Additionally, it has been studied for its potential in cancer therapy due to its ability to inhibit angiogenesis, the process by which new blood vessels form, thereby limiting tumor growth. Squalamine's mechanism of action involves disrupting cellular membranes and interfering with essential cellular processes. Its safety profile and efficacy are subjects of ongoing research, particularly in the context of drug development and therapeutic applications.
Formula:C34H65N3O5S
InChI:InChI=1/C34H65N3O5S/c1-23(2)31(42-43(39,40)41)12-9-24(3)27-10-11-28-32-29(14-16-34(27,28)5)33(4)15-13-26(21-25(33)22-30(32)38)37-20-8-19-36-18-7-6-17-35/h23-32,36-38H,6-22,35H2,1-5H3,(H,39,40,41)/t24-,25-,26+,27-,28+,29+,30-,31-,32+,33+,34-/m1/s1
InChI key:InChIKey=UIRKNQLZZXALBI-MSVGPLKSSA-N
SMILES:O[C@H]1[C@@]2([C@@]([C@]3(C)[C@@](C1)(C[C@@H](NCCCNCCCCN)CC3)[H])(CC[C@@]4(C)[C@]2(CC[C@@]4([C@@H](CC[C@@H](OS(=O)(=O)O)C(C)C)C)[H])[H])[H])[H]
Synonyms:
  • (3beta,5alpha,7alpha,24R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-7-hydroxycholestan-24-yl hydrogen sulfate
  • (3β,5α,7α)-3-[[3-((4-Aminobutyl)amino)propyl]amino]cholestane-7,24-diol-24-hydrogen sulfate
  • Cholestane-7,24-diol, 3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
  • Msi 1256
  • ENT-01 free base
  • Squalamine
  • ENT 01 free base
  • Squalamine, >98%
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