CAS 14875-96-8

Heme

Description:

Heme is a complex organic molecule that plays a crucial role in various biological processes, primarily as a prosthetic group in hemoproteins such as hemoglobin and myoglobin. It consists of an iron ion contained within a porphyrin ring, which is a cyclic structure made up of four pyrrole subunits linked by methine bridges. The iron in heme can exist in different oxidation states, allowing it to participate in redox reactions and bind to oxygen, carbon monoxide, and other small molecules. Heme is essential for oxygen transport and storage in living organisms, as well as for electron transfer in cellular respiration. Its structure allows for the reversible binding of oxygen, making it vital for aerobic metabolism. Additionally, heme is involved in various enzymatic reactions, including those catalyzed by cytochromes, which are important for drug metabolism and detoxification processes. The CAS number 14875-96-8 specifically identifies heme, highlighting its significance in biochemistry and medicine.

Formula: C₃₄H₃₀FeN₄O₄·2H

InChI: InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13?,27-14?,28-15?,29-14-,30-15-,31-16-,32-16?;

InChI key: InChIKey=KABFMIBPWCXCRK-ADOXYXQCSA-L

SMILES: C(CC([O-])=O)C=1C=2[N-]3[Fe+2]45[N]6=C(C2)C(CCC([O-])=O)=C(C)C6=CC=7[N-]4C(C=C8[N]5=C(C=C3C1C)C(C=C)=C8C)=C(C=C)C7C.[H+]

Synonyms:

• 1,3,5,8-Tetramethyl-2,4-divinylporphine-6,7-dipropionic acid ferrous complex
• 21H,23H-Porphine, ferrate(2-) deriv.
• 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, iron complex
• Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-, dihydrogen, (SP-4-2)-
• Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N²¹,N²²,N²³,N²⁴]-, dihydrogen, (SP-4-2)-
• Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN21,κN22,κN23,κN24]-, hydrogen (1:2), (SP-4-2)-
• Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, dihydrogen, (SP-4-2)-
• Ferrate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]-, hydrogen (1:2), (SP-4-2)-
• Ferroheme
• Ferroprotoporphyrin IX
• Hem Fe
• Heme
• Heme b
• Hydrogen [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-κN²¹,κN²²,κN²³,κN²⁴]ferrate (heme)
• Iron protoporphyrin
• Iron protoporphyrin IX
• Iron(II) protoporphyrin IX
• Nsc 267100
• Protoheme
• Protoheme IX
• Protoporphyrin IX, iron deriv.
• Protoporphyrin, iron complex
• Reduced hematin
• [3,8,13,17-Tetramethyl-7,12-divinyl-21H,23H-porphine-2,8-dipropanoato(4-)-N21,N22,N23,N24]ferrate(2-) de dihydrogene (SP-4-2)
• [Dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)]iron

Heme

CAS: 14875-96-8

Formula: C₃₄H₃₀FeN₄O₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 616.4873

Ref: IN-DA00AOIN

Ferroheme

CAS: 14875-96-8

Ferroheme

Purity: ≥95%

Molecular weight: 616.49g/mol

Ref: 54-BUP08076

Hematin (Fe(II) Protoporphyrin IX)

CAS: 14875-96-8

Formula: C₃₄H₃₂FeN₄O₄

Molecular weight: 616.50

Ref: 4Z-H-042001

Ferroheme

CAS: 14875-96-8

Ferroheme: iron-containing porphyrin in hemoglobin and other hemeproteins; colors tissues.

Formula: C₃₄H₃₂FeN₄O₄

Purity: 97.63%

Color and Shape: Solid

Molecular weight: 616.49

Ref: TM-T8948

Ferroprotoporphyrin IX

CAS: 14875-96-8

Stability Light Sensitive
Applications Ferroprotoporphyrin IX is a metabolite formed during biosynthesis and is used to evaluate iron nutrition and metabolism. It is also an iron containing cofactor that is involved with a wide range of cellular functions including oxygen transport.
References Labbe, R.F., et. al.: Clin. Chem., 45, 146 (1999); Yuan, X., et al.: Proc. Natl. Acad. Sci. USA 113, E5144 (2016);

Formula: C₃₄H₃₂FeN₄O₄₂

Color and Shape: Neat

Molecular weight: 616.49

Ref: TR-F307610

HEME

CAS: 14875-96-8

Heme is an iron-containing, non-protein molecule that is essential for life. Heme has a variety of biochemical properties and is important in the regulation of vital biological processes such as oxygen transport and metabolism of nitrogenous compounds. Heme can be found in two forms: heme A and heme B. The former consists of the protein globin combined with ferrous ion, while the latter is formed by the combination of protoporphyrin IX with ferrous ion. The synthesis of heme occurs through a series of reactions that involve oxidation and reduction reactions. The protoheme synthesis pathway results in the production of erythrocruorin, which is then converted to hemes A or B depending on its position in the globin protein chain. In addition to being an important cofactor for enzymes such as cytochrome c oxidase (complex IV), heme also functions as a substrate for heme oxygenase, which removes it from circulation to produce biliver

Formula: C₃₄H₃₂FeN₄O₄

Purity: Min. 95%

Molecular weight: 616.5 g/mol

Ref: 3D-PAA87596