CAS 148849-67-6: Ivabradine hydrochloride

Description: Ivabradine hydrochloride is a pharmacological agent primarily used in the treatment of certain heart conditions, particularly chronic stable angina and heart failure. It functions as a selective inhibitor of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, specifically targeting the HCN4 subtype, which plays a crucial role in regulating heart rate. This mechanism allows Ivabradine to reduce heart rate without affecting myocardial contractility or blood pressure. The substance is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. Ivabradine hydrochloride is characterized by its relatively low molecular weight and specific structural features that contribute to its pharmacological activity. It is generally well-tolerated, with common side effects including bradycardia and visual disturbances due to its action on retinal HCN channels. The compound is classified as a cardiovascular agent and is often prescribed in conjunction with other medications to optimize heart function and improve patient outcomes in cardiovascular diseases.

Formula: C₂₇H₃₆N₂O₅·ClH

InChI: InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1

InChI key: InChIKey=HLUKNZUABFFNQS-ZMBIFBSDSA-N

SMILES: Cl.O=C1N(CCC2=CC(OC)=C(OC)C=C2C1)CCCN(C)CC3C4=CC(OC)=C(OC)C=C4C3

Synonyms:

• 2H-3-Benzazepin-2-one, 3-[3-[[(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride, (S)-
• 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)
• 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride
• 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
• 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride
• 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
• Bicyclo[4.2.0]octane, 2H-3-benzazepin-2-one deriv.
• Corlanor
• Corlentor
• Ivabradine HCl
• Procoralan
• Ivabradine hydrochloride

Ivabradine Hydrochloride

CAS: 148849-67-6155974-00-8

• Formula: C₂₇H₃₆N₂O₅·HCl
• Purity: >98.0%(HPLC)(N)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 505.05

2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)

CAS: 148849-67-6

• Formula: C₂₇H₃₇ClN₂O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 505.0461

Ivabradine hydrochloride

CAS: 148849-67-6

• Formula: C₂₇H₃₆N₂O₅·HCl
• Purity: ≥ 98.0%
• Color and Shape: White to beige powder or crystals
• Molecular weight: 505.05

Ivabradine-d6 HCl

CAS: 148849-67-6

• Formula: C₂₇H₃₀D₆N₂O₅·HCl
• Color and Shape: White To Off-White Solid
• Molecular weight: 474.63 36.46

Ivabradine HCl

CAS: 148849-67-6

• Formula: C₂₇H₃₆N₂O₅·HCl
• Color and Shape: White To Off-White Solid
• Molecular weight: 468.59 36.46

Ivabradine Impurity 6 HCl

CAS: 148849-67-6

• Formula: C₂₇H₃₇ClN₂O₅·HCl
• Color and Shape: White To Off-White Solid
• Molecular weight: 505.06 36.46

Ivabradine hydrochloride

CAS: 148849-67-6

Ivabradine HCl (S 16257-2) is an If inhibitor (IC50: 2.9 μM) and SA node HCN …

• Formula: C₂₇H₃₇ClN₂O₅
• Purity: 98.6% - 99.73%
• Color and Shape: Solid
• Molecular weight: 505.05

Ivabradine Hydrochloride

CAS: 148849-67-6

Applications Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial …

• Formula: C₂₇H₃₆N₂O₅·ClH
• Color and Shape: White To Light Yellow
• Molecular weight: 505.05

Ivabradine HCl

CAS: 148849-67-6

Inhibitor of hERG potassium channel

• Formula: C₂₇H₃₆N₂O₅•HCl
• Purity: Min. 98 Area-%
• Color and Shape: White/Off-White Solid
• Molecular weight: 505.05 g/mol

Ivabradine HCl - Bio-X ™

CAS: 148849-67-6

Ivabradine is a HCN channel blocker that is used to reduce the risk of hospitalization …

• Formula: C₂₇H₃₆N₂O₅•HCl
• Purity: Min. 99 Area-%
• Color and Shape: Powder
• Molecular weight: 505.05 g/mol

3-(Prop-2-en-1-yl) Ivabradine

CAS: 148849-67-6

• Formula: C₁₅H₁₉NO₃
• Color and Shape: Neat
• Molecular weight: 261.316

Ivabradine-d4 Hydrochloride

CAS: 148849-67-6

• Formula: C₂₇D₄H₃₂N₂O₅·HCl
• Color and Shape: Neat
• Molecular weight: 509.071