CAS 148849-67-6

Ivabradine hydrochloride

Description:

Ivabradine hydrochloride is a pharmacological agent primarily used in the treatment of certain heart conditions, particularly chronic stable angina and heart failure. It functions as a selective inhibitor of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, specifically targeting the HCN4 subtype, which plays a crucial role in regulating heart rate. This mechanism allows Ivabradine to reduce heart rate without affecting myocardial contractility or blood pressure. The substance is typically administered in its hydrochloride salt form, enhancing its solubility and bioavailability. Ivabradine hydrochloride is characterized by its relatively low molecular weight and specific structural features that contribute to its pharmacological activity. It is generally well-tolerated, with common side effects including bradycardia and visual disturbances due to its action on retinal HCN channels. The compound is classified as a cardiovascular agent and is often prescribed in conjunction with other medications to optimize heart function and improve patient outcomes in cardiovascular diseases.

Formula: C₂₇H₃₆N₂O₅·ClH

InChI: InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30;/h12-14,16,21H,6-11,15,17H2,1-5H3;1H/t21-;/m1./s1

InChI key: InChIKey=HLUKNZUABFFNQS-ZMBIFBSDSA-N

SMILES: C(N(CCCN1C(=O)CC=2C(CC1)=CC(OC)=C(OC)C2)C)[C@@H]3C=4C(C3)=CC(OC)=C(OC)C4.Cl

Synonyms:

• 2H-3-Benzazepin-2-one, 3-[3-[[(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride, (S)-
• 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)
• 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride
• 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
• 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride
• 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
• Bicyclo[4.2.0]octane, 2H-3-benzazepin-2-one deriv.
• Corlanor
• Corlentor
• Ivabradine HCl
• Procoralan

Ivabradine Hydrochloride

CAS: 148849-67-6, 155974-00-8

Formula: C₂₇H₃₆N₂O₅·HCl

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 505.05

Ref: 3B-I0847

2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)

CAS: 148849-67-6

Formula: C₂₇H₃₇ClN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 505.0461

Ref: IN-DA001L8M

Ivabradine HCl

CAS: 148849-67-6

Formula: C₂₇H₃₆N₂O₅·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 468.59 36.46

Ref: 4Z-I-302

Ivabradine hydrochloride

CAS: 148849-67-6

Ivabradine hydrochloride

Purity: ≥98%

Molecular weight: 505.05g/mol

Ref: 54-BUP15665

Ivabradine-d6 HCl

CAS: 148849-67-6

Formula: C₂₇H₃₀D₆N₂O₅·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 474.63 36.46

Ref: 4Z-I-307

Ivabradine hydrochloride

CAS: 148849-67-6

Formula: C₂₇H₃₆N₂O₅·HCl

Purity: ≥ 98.0%

Color and Shape: White to beige powder or crystals

Molecular weight: 505.05

Ref: 7W-GK8601

Ivabradine Impurity 6 HCl

CAS: 148849-67-6

Formula: C₂₇H₃₇ClN₂O₅·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 505.06 36.46

Ref: 4Z-I-3021

Ivabradine hydrochloride

CAS: 148849-67-6

Ivabradine HCl (S 16257-2) is an If inhibitor (IC50: 2.9 μM) and SA node HCN channel blocker that slows heart rate.

Formula: C₂₇H₃₇ClN₂O₅

Purity: 99% - 99.73%

Color and Shape: Solid

Molecular weight: 505.05

Ref: TM-T2535

Ivabradine Hydrochloride

Controlled Product

CAS: 148849-67-6

Applications Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),

Formula: C₂₇H₃₆N₂O₅·ClH

Color and Shape: Neat

Molecular weight: 505.05

Ref: TR-I940500

Ivabradine HCl

CAS: 148849-67-6

Inhibitor of hERG potassium channel

Formula: C₂₇H₃₆N₂O₅•HCl

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 505.05 g/mol

Ref: 3D-FI65048

Ivabradine HCl - Bio-X ™

CAS: 148849-67-6

Ivabradine is a HCN channel blocker that is used to reduce the risk of hospitalization for worsening heart failure and used in the treatment of symptomatic heart failure. This drug acts by inhibiting the “funny” channel pacemaker current (If) which results in a lower heart rate and allows for more blood flow to the myocardium.

Formula: C₂₇H₃₆N₂O₅•HCl

Purity: Min. 99 Area-%

Color and Shape: Powder

Molecular weight: 505.05 g/mol

Ref: 3D-BI164596

2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)

CAS: 148849-67-6

Purity: 98%

Molecular weight: 505.0499878

Ref: 10-F861923

3-(Prop-2-en-1-yl) Ivabradine

Controlled Product

CAS: 148849-67-6

Formula: C₁₅H₁₉NO₃

Color and Shape: Neat

Molecular weight: 261.316

Ref: TR-P695430

Ivabradine-d4 Hydrochloride

Controlled Product

CAS: 148849-67-6

Formula: C₂₇D₄H₃₂N₂O₅·HCl

Color and Shape: Neat

Molecular weight: 509.071

Ref: TR-I940503