CAS 148892-91-5

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

Description:

5'-Guanylylimidodiphosphate trisodium, commonly referred to as GMPPNP, is a non-hydrolyzable analog of guanosine triphosphate (GTP) and serves as a potent nucleotide analog in biochemical research. It is characterized by its ability to mimic GTP, thereby influencing various GTP-binding proteins and enzymes, particularly in studies involving signal transduction and molecular biology. The compound is typically supplied as a trisodium salt, enhancing its solubility in aqueous solutions. GMPPNP is often utilized in experiments to investigate the mechanisms of GTPase activity and to stabilize protein conformations in the presence of GTP-binding proteins. Its structural features include a guanine base, a ribose sugar, and a diphosphate moiety, with the imido group providing resistance to hydrolysis. This stability makes it a valuable tool for probing the dynamics of GTP-dependent processes in cellular systems. As with many nucleotide analogs, GMPPNP's interactions can provide insights into the regulatory roles of nucleotides in cellular signaling pathways.

Formula: C₁₀H₁₄N₆Na₃O₁₃P₃

InChI: InChI=1/C10H17N6O13P3.3Na/c11-10-13-7-4(8(19)14-10)12-2-16(7)9-6(18)5(17)3(28-9)1-27-32(25,26)29-31(23,24)15-30(20,21)22;;;/h2-3,5-6,9,17-18H,1H2,(H,25,26)(H3,11,13,14,19)(H4,15,20,21,22,23,24);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

SMILES: C(C1C(C(C(n2cnc3c2[nH]c(=N)nc3O)O1)O)O)OP(=O)(O)OP(=O)(NP(=O)(O)O)O.[Na].[Na].[Na]

Synonyms:

• Guanosine 5'-[Β,Γ-Imido]Triphosphate Trisodium Salt
• Β:Γ-Imidoguanosine 5'-Triphosphate Trisodium Salt
• 5μ-Guanylyl-imidodiphosphate hydrate trisodium salt, GMP-PNP, Gpp(NH)p, β:γ-Imidoguanosine 5μ-triphosphate hydrate trisodium salt
• Guanosine 5μ-[β,γ-imido]triphosphate hydrate trisodium salt
• trisodium 5'-O-[({[(hydroxyphosphinato)amino]phosphinato}oxy)phosphinato]guanosine

Guanosine 5′-(β,γ-imido)triphosphate trisodium salt

CAS: 148892-91-5

Formula: C₁₀H₁₄N₆Na₃O₁₃P₃

Purity: 85%

Color and Shape: Solid

Molecular weight: 588.1412

Ref: IN-DA001L9C

Guanylyl Imidodiphosphate Trisodium Salt (90%)

Controlled Product

CAS: 148892-91-5

Applications Guanylyl Imidodiphosphate is a non-hydrolyzable GTP analog which can irreversibly activate G-proteins in the presence of magnesium. Affects protein synthesis and essential in protein transolocation.
References Terry, B. et al.: J. Biol. Chem., 255, 10532 (1980); J. Biol. Chem., 250, 4418 (1975); R. G. Yount, Methods in Ezymology, 1974, 38, 420-427.

Formula: C₁₀H₁₄N₆Na₃O₁₃P₃

Purity: 90%

Color and Shape: Neat

Molecular weight: 588.14

Ref: TR-G844700

Guanylyl Imidodiphosphate

CAS: 148892-91-5

Guanylyl Imidodiphosphate trisodium, a stable GTP analogue, activates ARF and stimulates adenylate cyclase, aiding in protein synthesis research.

Formula: C₁₀H₁₄N₆Na₃O₁₃P₃

Color and Shape: Solid

Molecular weight: 588.142

Ref: TM-T21803