CAS 14899-36-6

Dexamethasone palmitate

Description:

Dexamethasone palmitate is a synthetic derivative of dexamethasone, a potent glucocorticoid used primarily for its anti-inflammatory and immunosuppressive properties. This compound is characterized by the esterification of dexamethasone with palmitic acid, which enhances its lipophilicity and alters its pharmacokinetic profile. Dexamethasone palmitate is typically administered via intramuscular or subcutaneous routes, allowing for prolonged release and sustained therapeutic effects. It exhibits anti-inflammatory activity by inhibiting the release of inflammatory mediators and modulating immune responses. The substance is often utilized in various medical applications, including the treatment of conditions such as allergies, autoimmune disorders, and certain types of cancer. Its formulation may include various excipients to improve stability and solubility. As with other corticosteroids, potential side effects may include metabolic changes, increased susceptibility to infections, and adrenal suppression, necessitating careful monitoring during treatment. Overall, dexamethasone palmitate represents a valuable tool in the management of inflammatory and autoimmune conditions.

Formula: C₃₈H₅₉FO₆

InChI: InChI=1S/C38H59FO6/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-34(43)45-26-33(42)38(44)27(2)23-31-30-20-19-28-24-29(40)21-22-35(28,3)37(30,39)32(41)25-36(31,38)4/h21-22,24,27,30-32,41,44H,5-20,23,25-26H2,1-4H3/t27-,30+,31+,32+,35+,36+,37+,38+/m1/s1

InChI key: InChIKey=WDPYZTKOEFDTCU-WDJQFAPHSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COC(CCCCCCCCCCCCCCC)=O)=O)O)[H]

Synonyms:

• (11Beta,16Alpha)-9-Fluoro-11,17-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl Hexadecanoate
• (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxohexadecyl)oxy]pregna-1,4-diene-3,20-dione
• DXM-21-palmitate
• Dexamethasone-21-palmitate
• Limethason
• Limethasone
• Lipotalon
• Palmitic acid, 21-ester with 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxohexadecyl)oxy]-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-palmitate

Dexamethasone palmitate

CAS: 14899-36-6

Formula: C₃₈H₅₉FO₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 630.8699

Ref: IN-DA00AC9K

Dexamethasone palmitate

CAS: 14899-36-6

Dexamethasone palmitate

Purity: ≥98%

Molecular weight: 630.87g/mol

Ref: 54-BUP11282

Dexamethasone Palmitate

CAS: 14899-36-6

Formula: C₃₈H₅₉FO₆

Molecular weight: 630.88

Ref: 4Z-D-3698

Dexamethasone 21-Palmitate-d31

Controlled Product

CAS: 14899-36-6

Applications A labelled orticosteroid prodrug for the treatment of eye disorders.
References Benameur, H., et al.: J. Pharm. Pharmacol., 47, 812 (1995), Tauchi, Y., et al.: Biol. Pharm. Bull., 24, 925 (2001), Chono, S., et al.: J. Drug Targeting, 13, 407 (2005),

Formula: C₃₈D₃₁H₂₈FO₆

Color and Shape: Neat

Molecular weight: 662.06

Ref: TR-D298832

Dexamethasone 21-Palmitate

Controlled Product

CAS: 14899-36-6

Applications A corticosteroid prodrug for the treatment of eye disorders.
References Benameur, H., et al.: J. Pharm. Pharmacol., 47, 812 (1995), Tauchi, Y., et al.: Biol. Pharm. Bull., 24, 925 (2001), Chono, S., et al.: J. Drug Targeting, 13, 407 (2005),

Formula: C₃₈H₅₉FO₆

Color and Shape: Neat

Molecular weight: 630.87

Ref: TR-D298830

Dexamethasone 21-palmitate

Controlled Product

CAS: 14899-36-6

Dexamethasone 21-palmitate is a sample preparation agent that is used to prevent the loss of cells or particles during storage. It can be used in vitro as an immunosuppressant to inhibit lymphocyte transformation, particle, and cell nuclei formation. Dexamethasone 21-palmitate is also used for eye disorders, inflammatory bowel disease, and human macrophages. The product may also be used for choroidal neovascularization in eye disorders.

Formula: C₃₈H₅₉FO₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 630.87 g/mol

Ref: 3D-FD21400

Dexamethasone palmitate

CAS: 14899-36-6

DXP, a lipophilic prodrug of Dexamethasone, has 47x less glucocorticoid receptor affinity; it's an agonist & anti-inflammatory.

Formula: C₃₈H₅₉FO₆

Purity: 99.28%

Color and Shape: Solid

Molecular weight: 630.87

Ref: TM-T15102