CAS 149-73-5

Trimethyl orthoformate

Description:

Trimethyl orthoformate, with the CAS number 149-73-5, is an organic compound classified as an orthoformate. It is characterized by its molecular formula C5H12O4 and typically appears as a colorless, volatile liquid with a sweet, fruity odor. This compound is known for its reactivity, particularly in the presence of alcohols and acids, where it can serve as a methoxycarbonylating agent. Trimethyl orthoformate is soluble in organic solvents such as ether and alcohol but has limited solubility in water. It is commonly used in organic synthesis, particularly in the preparation of esters and as a reagent in the formation of acylals. Additionally, it can act as a protecting group for alcohols in synthetic pathways. Due to its flammable nature, it should be handled with care, following appropriate safety protocols to mitigate risks associated with its volatility and reactivity.

Formula: C₄H₁₀O₃

InChI: InChI:1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3

InChI key: InChIKey=PYOKUURKVVELLB-UHFFFAOYSA-N

SMILES: C(OC)(OC)OC

Synonyms:

• 2-Methoxyacetaldehyde dimethyl acetal
• Methoxymethylal
• Methyl orthoformate
• Nsc 147479
• Orthoameisensaeure-Trimethylester
• Orthoformiate de trimethyle
• Orthoformic acid methyl ester
• Orthoformic acid, trimethyl ester
• Ortoformiato De Trimetilo
• Perma-Flo OF
• Trimethoxymethane
• Trimethyl Orthoformate
• Trimethylorthoformiat
• Trimethyl ortho formate
• methoxymethanediol
• Trimethyl Orthoformate(TMOF)
• Methane, trimethoxy-
• Thrimethyl orthoformate
• Orthomravencan methylnaty
• orthoformicacidmethylester
• CH(OCH3)3
• TMOF
• Methylester kyseliny orthomravenci
• methylesterkyselinyorthomravenci(czech)
• TRIMETHYL-O-FORMATE
• trimethoxy-methan
• orthomravencanmethylnaty
• Trimethylester kyseliny orthomravenci
• trimethylesterkyselinyorthomravenci
• methylesterkyselinyorthomravenci

Trimethyl Orthoformate

CAS: 149-73-5

Formula: C₄H₁₀O₃

Purity: >98.0%(GC)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 106.12

Ref: 3B-O0068

Trimethyl orthoformate, 99%

CAS: 149-73-5

Trimethyl orthoformate is used as a protecting group for aldehydes in organic synthesis, as an additive in polyurethane coatings and as a dehydrating agent in the preparation of surface modified colloidal silica nanoparticles. It is also used as a chemical intermediate in the preparation of vitamin

Formula: C₄H₁₀O₃

Purity: 99%

Color and Shape: Clear colorless, Liquid

Molecular weight: 106.12

Ref: 02-A13760

Trimethyl orthoformate

CAS: 149-73-5

Formula: HC(OCH₃)₃

Molecular weight: 106.12

Ref: 7W-GK2714

Trimethyl orthoformate

CAS: 149-73-5

Formula: C₄H₁₀O₃

Purity: 98.0%

Color and Shape: Liquid, Clear colourless liquid

Molecular weight: 106.121

Ref: 10-F095019

Trimethyl Orthoformate

Controlled Product

CAS: 149-73-5

Applications Trimethyl Orthoformate is a reagent in the synthesis of CDK2/Cyclin A as antitumor agents derived from 3-aminopyrazole molecules. Also used in the preparation of PLD1/PLD2 selective inhibitors that decrease invasive migration of glioblastoma cells often associated with tumor progression.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pevarello, P. et al.: J. Med. Chem., 48, 2944 (2005); O'Reilly, M. et al.: J. Med. Chem., 56, 2695 (2013);

Formula: C₄H₁₀O₃

Color and Shape: Neat

Molecular weight: 106.12

Ref: TR-T796490

Trimethyl orthoformate

CAS: 149-73-5

Trimethyl orthoformate is a glycoside that is used as a substrate for the production of methyl glycosides. It has been shown to have antibacterial activity in vitro against gram-positive bacteria and methicillin-resistant Staphylococcus aureus (MRSA). Trimethyl orthoformate can be synthesized by condensation of formaldehyde and methanol with sodium ethoxide, followed by hydrolysis with dilute acid. This compound can also be prepared from trimethylamine and formaldehyde with sodium ethoxide in acidic media. The reaction mechanism of this reaction involves the formation of an iminium ion intermediate, which undergoes nucleophilic attack by water followed by elimination of hydrogen cyanide to form the desired product. Methyl glycosides are formed when trimethyl orthoformate reacts with acetic anhydride or acetone. These compounds inhibit bacterial growth by inhibiting protein synthesis at the ribosome level

Formula: C₄H₁₀O₃

Purity: Min. 95%

Color and Shape: Clear Colourless Liquid

Molecular weight: 106.12 g/mol

Ref: 3D-FT60564

Trimethyl Orthoformate (TMOF) pure, 98%

CAS: 149-73-5

Formula: C₄H₁₀O₃

Purity: min. 98%

Color and Shape: Clear, Colourless, Liquid

Molecular weight: 106.12

Ref: SR-68989