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CAS 149003-01-0

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Dexrazoxane hydrochloride

Description:
Dexrazoxane hydrochloride is a synthetic compound primarily used as a cardioprotective agent in chemotherapy, particularly to mitigate the cardiotoxic effects of anthracycline antibiotics like doxorubicin. It functions as a topoisomerase II inhibitor and is known for its ability to chelate iron, thereby reducing oxidative stress and free radical formation during treatment. The substance appears as a white to off-white crystalline powder and is soluble in water, which facilitates its administration in clinical settings. Dexrazoxane hydrochloride is typically administered intravenously and is indicated for use in patients undergoing cancer treatment, particularly those at high risk for anthracycline-induced cardiotoxicity. Its mechanism of action involves the inhibition of DNA damage caused by anthracyclines, thereby protecting cardiac tissue. While generally well-tolerated, potential side effects may include myelosuppression and gastrointestinal disturbances. As with any chemotherapeutic adjunct, careful consideration of patient-specific factors is essential for its effective and safe use.
Formula:C11H16N4O4·ClH
InChI:InChI=1/C11H16N4O4.ClH/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14;/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19);1H/t7-;/m0./s1
InChI key:InChIKey=BIFMNMPSIYHKDN-FJXQXJEOSA-N
SMILES:C([C@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
Synonyms:
  • (S)-4,4'-(1-Methyl-1,2-Ethanediyl)Bis-2,6-Piperazinedione Hydrochloride
  • 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, hydrochloride, (S)-
  • 2,6-Piperazinedione, 4,4′-[(1S)-1-methyl-1,2-ethanediyl]bis-, hydrochloride
  • 2,6-Piperazinedione, 4,4′-[(1S)-1-methyl-1,2-ethanediyl]bis-, hydrochloride (1:?)
  • 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione hydrochloride
  • Cardioxan
  • Cardioxane
  • Dexrazoxane HCl
  • ICRF 187 hydrochloride
  • Savene
  • See more synonyms
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Found 3 products.