CAS 149022-22-0: Amikacin Sulphate
Description:Amikacin sulfate is an aminoglycoside antibiotic primarily used to treat serious infections caused by Gram-negative bacteria. It is a semi-synthetic derivative of kanamycin and exhibits a broad spectrum of antibacterial activity, particularly against strains resistant to other aminoglycosides. The compound is typically administered via injection and is known for its effectiveness in treating infections such as pneumonia, sepsis, and urinary tract infections. Amikacin sulfate works by inhibiting bacterial protein synthesis, ultimately leading to cell death. Its pharmacokinetics include good tissue penetration, with a relatively long half-life compared to other aminoglycosides, allowing for less frequent dosing. However, it is important to monitor renal function during treatment, as nephrotoxicity is a potential side effect. Additionally, ototoxicity can occur, particularly with prolonged use or higher doses. Overall, amikacin sulfate is a valuable therapeutic agent in the arsenal against multidrug-resistant bacterial infections, but its use must be carefully managed to minimize adverse effects.
Formula:C22H45N5O17S
InChI:InChI=1/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
- Synonyms:
- Amikacin Sulfate
- Amikacin Disulfate Salt
- 4-Amino-N-[5-Amino-2-[4-Amino-3,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydropyran-2-Yl]Oxy-4-[6-(Aminomethyl)-3,4,5-Trihydroxy-Tetrahydropyran-2-Yl]Oxy-3-Hydroxy-Cyclohexyl]-2-Hydroxy-Butanamide Disulfate Salt
- 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
- (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (salt)
- Amikacin Sulfate Salt
- (2R)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (salt)
- (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide sulfate (1:2)
- Amikacin Sulfate 1:1.8