CAS 149107-84-6: 7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III

Description: 7,10-Bis[O-(triethylsilyl)]-10-deacetyl Baccatin III is a synthetic derivative of Baccatin III, which is a natural product derived from the Pacific yew tree, Taxus brevifolia. This compound is characterized by the presence of two triethylsilyl groups attached to the hydroxyl functionalities at the 7 and 10 positions of the Baccatin III structure. The introduction of these silyl groups enhances the compound's stability and solubility, making it useful in various chemical applications, particularly in the synthesis of taxane-based anticancer agents. The compound is typically a white to off-white solid and is soluble in organic solvents such as dichloromethane and acetone. Its molecular structure contributes to its potential biological activity, particularly in inhibiting cell division, which is a key mechanism in cancer treatment. As with many silyl derivatives, it may also exhibit unique reactivity patterns in organic synthesis, making it a valuable intermediate in pharmaceutical chemistry.

Formula: C₄₁H₆₄O₁₀Si₂

InChI: InChI=1/C41H64O10Si2/c1-12-52(13-2,14-3)50-30-23-31-40(25-47-31,49-27(8)42)34-36(48-37(45)28-21-19-18-20-22-28)41(46)24-29(43)26(7)32(38(41,9)10)33(35(44)39(30,34)11)51-53(15-4,16-5)17-6/h18-22,29-31,33-34,36,43,46H,12-17,23-25H2,1-11H3/t29-,30-,31+,33+,34?,36-,39+,40-,41+/m0/s1

Synonyms:

• (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4a,8,13,13-tetramethyl-4,6-bis[(triethylsilyl)oxy]-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one-

Paclitaxel Impurity 20

CAS: 149107-84-6

• Formula: C₄₁H₆₄O₁₀Si₂
• Molecular weight: 773.12

7,10-Bis[O-(triethylsilyl)]-10-deacetyl baccatin III

CAS: 149107-84-6

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• Formula: C₄₁H₆₄O₁₀Si₂
• Purity: Min. 95%
• Molecular weight: 773.11 g/mol