CAS 14913-33-8

Transplatin

Description:

Transplatin, with the CAS number 14913-33-8, is a platinum-based compound that is structurally similar to cisplatin, a well-known chemotherapeutic agent. However, unlike cisplatin, which has proven effective in cancer treatment, transplatin exhibits significantly lower antitumor activity. The compound is characterized by its square planar geometry, typical of platinum(II) complexes, and its ability to form coordination bonds with DNA, although its binding mode differs from that of cisplatin. Transplatin's mechanism of action involves the formation of DNA cross-links, but these cross-links are less effective in disrupting DNA replication and transcription, leading to its reduced efficacy. Additionally, transplatin has been studied for its potential to induce different cellular responses compared to cisplatin, including variations in toxicity and resistance mechanisms. Its solubility and stability in aqueous solutions are also notable, influencing its behavior in biological systems. Overall, while transplatin shares some chemical properties with cisplatin, its therapeutic potential is limited, making it primarily of interest in research contexts rather than clinical applications.

Formula: Cl₂H₆N₂Pt

InChI: InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key: InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L

SMILES: [Pt+2]([Cl-])([Cl-])([NH3])[NH3]

Synonyms:

• (SP-4-1)-Diamminedichloroplatinum
• Diamminedichloro-Platinu(Sp-4-1)
• Dichlorodiamineplatinum(Ii)
• NSC 131558
• Nsc131558
• Platinum(2+) Chloride Ammoniate (1:2:2)
• Platinum(4+) Chloride Azanide (1:2:2)
• Platinum, diamminedichloro-, (SP-4-1)-
• Platinum, diamminedichloro-, trans-
• Trans-Diaminedichloroplatinum
• Trans-Diamminedichloroplatinum
• Trans-Dichlorodiammineplatinum
• Trans-Platinumdiamminedichloride
• Transplatin
• trans-DDP
• trans-Diamminedichloroplatinum(II)
• trans-Dichlorodiammine platinum
• trans-Dichlorodiammineplatinum(II)
• trans-Platinum(II) ammonium chloride

trans-Diamminedichloroplatinum(II), Pt 64.5% min

CAS: 14913-33-8

trans-Diamminedichloroplatinum(II) acts as a reversible RNA-protein cross-linking agent. It is also used in plating baths. It reacts with DNA after hydrolysis to get both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. This Thermo Scientific

Formula: Cl₂H₆N₂Pt

Purity: 64.5%

Molecular weight: 300.05

Ref: 02-010472

Transplatin

CAS: 14913-33-8

Transplatin

Color and Shape: Light Yellow

Ref: 47-544

CISPLATIN IMPURITY A CRS

CAS: 14913-33-8

CISPLATIN IMPURITY A CRS

Formula: H₄Cl₂N₂Pt

Color and Shape: Powder

Molecular weight: 298.0352

Ref: 41-Y0001018

Transplatin

CAS: 14913-33-8

Inorganic or organic compounds of precious metals, whether or not chemically defined, or amalgams of precious metals, nesoi

Formula: Cl₂H₆N₂Pt

Color and Shape: Light Yellow Powder

Molecular weight: 300.05

Ref: 45-1672803

Platinum, diamminedichloro-, (SP-4-1)-

CAS: 14913-33-8

Formula: Cl₂H₆N₂Pt

Purity: 98%

Color and Shape: Solid

Molecular weight: 300.0450

Ref: IN-DA001LFN

trans-Platinum(II)diammine dichloride

CAS: 14913-33-8

trans-Platinum(II)diammine dichloride

Purity: 98%

Molecular weight: 300.05g/mol

Ref: 54-IN12328

Cisplatinum EP Impurity A (Transplatin)

CAS: 14913-33-8

Formula: Cl₂H₆N₂Pt

Molecular weight: 300.05

Ref: 4Z-C-236003

Transplatin

CAS: 14913-33-8

Formula: H₆Cl₂N₂Pt

Purity: >98.0%(T)

Color and Shape: Light yellow to Yellow powder to crystal

Molecular weight: 300.05

Ref: 3B-T4176

trans-Dichlorodiamine platinum(II); 99.95% (metals basis)

CAS: 14913-33-8

Formula: Pt(NH₃)₂Cl₂

Molecular weight: 300.06

Ref: 7W-GX1443

Cisplatin EP Impurity A

CAS: 14913-33-8

Formula: Cl₂H₆N₂Pt

Molecular weight: 300.05

Ref: ST-EA-CP-C78001

Transplatin

CAS: 14913-33-8

Applications Transplatin is the trans stereoisomer impurity of Cisplatin (C499500), an antineoplastic used in the treatment of sarcomas, some carcinomas, lymphomas, and germ cell tumors. Transplatin binds to DNA but does not exhibit the same useful pharmacological effect as its cis stereoisomer.
References Cersosimo, R.J.: Cancer Treat. Rev., 16, 195 (1989); Takeiri, A. et al.: Genes Environ., 29, 89 (2007); Giraud-Panis, M.-J. et al.: Pharmacol. Therap., 85, 175 (2000);

Formula: Cl₂H₆N₂Pt

Color and Shape: Light Yellow

Molecular weight: 300.04

Ref: TR-T714800

Cisplatin impurity A

CAS: 14913-33-8

Cisplatin impurity A is a platinum-based chemotherapeutic agent that binds to DNA and inhibits the synthesis of cellular proteins. Cisplatin impurity A has been shown to inhibit the growth of cancer cells in vitro and in vivo. This compound also inhibits the production of epidermal growth factor, which may be due to its ability to bind dna at tetrazolium dye adducts. The coordination geometry of cisplatin impurity A is octahedral with two axial bidentate chelating ligands, which allows it to bind both DNA and tubule cells.

Formula: (NH₃)₂Cl₂Pt

Color and Shape: Powder

Molecular weight: 300.05 g/mol

Ref: 3D-IC63739

trans-Dichlorodiammine platinum(II), 99%

CAS: 14913-33-8

trans-Dichlorodiammine platinum(II), 99%

Formula: transPt(NH₃)₂Cl₂

Purity: 99%

Color and Shape: light yellow xtl.

Molecular weight: 300.06

Ref: 08-78-0451

trans-Dichlorodiamineplatinum(II)

CAS: 14913-33-8

Formula: Cl₂H₆N₂Pt

Purity: 95%

Molecular weight: 300.05

Ref: 10-F320250