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CAS 149183-89-1

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9-Desmethyl Tetrabenazine

Description:
9-Desmethyl Tetrabenazine is a chemical compound that belongs to the class of tetrabenazine derivatives, primarily known for its role in the treatment of movement disorders, particularly in the management of hyperkinetic movement disorders such as Huntington's disease. It is characterized by its ability to inhibit the vesicular monoamine transporter 2 (VMAT2), which leads to a decrease in the release of monoamines, including dopamine, from presynaptic neurons. This mechanism of action helps to reduce excessive movement. The compound is typically administered in a pharmaceutical form and is subject to strict regulatory controls due to its potential side effects, which may include sedation, depression, and other neurological effects. Its chemical structure features a complex arrangement of aromatic rings and nitrogen-containing groups, contributing to its pharmacological properties. As with many medications, the efficacy and safety profile of 9-Desmethyl Tetrabenazine is evaluated through clinical studies, and it is important for healthcare providers to monitor patients for adverse reactions during treatment.
Formula:C18H25NO3
Synonyms:
  • 9-Hydroxy-3-isobutyl-10-methoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
  • 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9-hydroxy-10-methoxy-3-(2-methylpropyl)-
  • 9-Desmethyl Tetrabenazine
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