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CAS 14919-77-8

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Benserazide hydrochloride

Description:
Benserazide hydrochloride is a pharmaceutical compound primarily used as a peripheral decarboxylase inhibitor in the treatment of Parkinson's disease. It is often administered in combination with levodopa to enhance the latter's efficacy by preventing its conversion to dopamine outside the central nervous system, thereby increasing its availability in the brain. This compound is characterized by its white to off-white crystalline appearance and is soluble in water, which facilitates its formulation in various dosage forms. The molecular structure of benserazide includes a hydrazine moiety, contributing to its pharmacological activity. Its mechanism of action involves the inhibition of the enzyme aromatic L-amino acid decarboxylase, which is crucial for the metabolism of levodopa. Benserazide hydrochloride is typically well-tolerated, but like all medications, it may have side effects, including gastrointestinal disturbances and potential interactions with other drugs. Proper dosage and administration are essential to maximize therapeutic benefits while minimizing adverse effects.
Formula:C10H15N3O5·ClH
InChI:InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
InChI key:InChIKey=ULFCBIUXQQYDEI-UHFFFAOYSA-N
SMILES:C(NNC(C(CO)N)=O)C1=C(O)C(O)=C(O)C=C1.Cl
Synonyms:
  • (S)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
  • 2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochloride
  • <span class="text-smallcaps">DL</span>-Serine N<sup>2</sup>-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
  • <span class="text-smallcaps">DL</span>-Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide, monohydrochloride
  • Benserazide Hcl
  • DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
  • N-(<span class="text-smallcaps">DL</span>-Seryl)-N′-(2,3,4-trihydroxybenzyl)hydrazine hydrochloride
  • Ro 4-4602
  • Ro 4-4602/001
  • Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, monohydrochloride
  • See more synonyms
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