CAS 1492-18-8

Calcium folinate

Description:

Calcium folinate, also known as leucovorin or citrovorum factor, is a calcium salt of folinic acid, which is a derivative of folic acid. It is commonly used in medical applications, particularly as a medication to reduce the toxic effects of certain chemotherapy agents, such as methotrexate, by providing a source of reduced folate. This compound is characterized by its white to pale yellow crystalline appearance and is soluble in water, making it suitable for intravenous or oral administration. Calcium folinate plays a crucial role in cellular metabolism, particularly in the synthesis of nucleic acids and amino acids, which are essential for cell division and growth. Its mechanism of action involves the conversion to active forms of folate, which can bypass the metabolic block caused by antifolate drugs. Additionally, it is utilized in the treatment of megaloblastic anemia and as a supportive therapy in various cancer treatments. Safety and efficacy profiles are well-established, but it should be used under medical supervision due to potential interactions with other medications.

Formula: C₂₀H₂₃N₇O₇·Ca

InChI: InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/t12?,13-;/m0./s1

InChI key: InChIKey=BZPWXVJDMRBCMD-ZEDZUCNESA-N

SMILES: C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O.[Ca]

Synonyms:

• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Calcium 5-formyltetrahydrofolate
• Calcium <span class="text-smallcaps">L</span>-folinate
• Calcium Folinate
• Calcium Folinate(Folinic Acid)(Rg)
• Calcium L-Folinate
• Calcium leucovorin
• Calcium2-[4-[(2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6-Yl)Methylamino]Benzoyl] Aminopentanedioate
• Calciumfolinat
• Folidan
• Folinate De Calcium
• Folinate-SF calcium
• Folinato Calcico
• Folinic acid Calcium salt
• Folinic acid calcium salt USP28
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), L-
• L-Calcium Folinate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Lederfoline
• Leucovorin Calcium
• Leucovorin calcium salt
• LeucovorinCalcium
• Leucovorine calcium
• Nsc 3590
• Rescuvolin
• Wellcovorin
• calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate

Folinic Acid Calcium Salt

CAS: 1492-18-8

Stability Hygroscopic
Applications Folinic Acid Calcium Salt is a derivative of Folic Acid (F680300), a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Has been shown to be partially effective in the treatment children suffering from autism spectrum disorders (ASDs).
References Frye, R. et al.: Mol. Psych., 18, 369 (2013); Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Formula: C₂₀H₂₁N₇O₇·Ca

Color and Shape: Neat

Molecular weight: 511.5

Ref: TR-F680320

Calcium folinate

CAS: 1492-18-8

Dihydrofolate reductase activator; decreases methotrexate toxicity

Formula: C₂₀H₂₁CaN₇O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 511.50 g/mol

Ref: 3D-FC61510

Leucovorin calcium salt - Bio-X ™

CAS: 1492-18-8

Leucovorin is a folate analog drug that is used to treat the toxic effects of methotrexate and other antagonists of folate. It works by counteracting the toxic effects of methrotrexate by inhibiting the enzyme dihydrofolate reductase. It is used to increase the levels of folic acid and by strengthening the link between the active metabolite (5-FdUMP) and the enzyme thymidylate synthetase, leucovorin increases the action of fluorouracil. Additionally, in order to increase survival in patients undergoing palliative treatment for colorectal cancer, it is used in conjunction with 5-fluorouracil.

Formula: C₂₀H₂₃N₇O₇·Ca

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 513.52 g/mol

Ref: 3D-BC164621

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt

CAS: 1492-18-8

Formula: C₂₀H₂₁CaN₇O₇

Purity: 95%

Color and Shape: Solid, Slightly pale yellow - Yellow powder

Molecular weight: 511.508

Ref: 10-F036567

Folic Acid Related Compound A (Calcium Formyltetrahydrofolate) (DISCONTINUED)

CAS: 1492-18-8

Other vitamins and their derivatives, nesoi

Formula: C₂₀H₂₃N₇O₇·Ca

Color and Shape: Powder

Molecular weight: 513.12849

Ref: 45-1286027

Calcium Folinate RS

CAS: 1492-18-8

Color and Shape: White To Light Yellow Solid Crystalline Powder

Ref: 2K-1154000021