CAS 1492-18-8: Calcium folinate

Description: Calcium folinate, also known as leucovorin or citrovorum factor, is a calcium salt of folinic acid, which is a derivative of folic acid. It is commonly used in medical applications, particularly as a medication to reduce the toxic effects of certain chemotherapy agents, such as methotrexate, by providing a source of reduced folate. This compound is characterized by its white to pale yellow crystalline appearance and is soluble in water, making it suitable for intravenous or oral administration. Calcium folinate plays a crucial role in cellular metabolism, particularly in the synthesis of nucleic acids and amino acids, which are essential for cell division and growth. Its mechanism of action involves the conversion to active forms of folate, which can bypass the metabolic block caused by antifolate drugs. Additionally, it is utilized in the treatment of megaloblastic anemia and as a supportive therapy in various cancer treatments. Safety and efficacy profiles are well-established, but it should be used under medical supervision due to potential interactions with other medications.

Formula: C₂₀H₂₃N₇O₇·Ca

InChI: InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/t12?,13-;/m0./s1

InChI key: InChIKey=BZPWXVJDMRBCMD-ZEDZUCNESA-N

SMILES: [Ca].O=CN1C=2C(=O)N=C(N)NC2NCC1CNC3=CC=C(C=C3)C(=O)NC(C(=O)O)CCC(=O)O

Synonyms:

• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Calcium 5-formyltetrahydrofolate
• Calcium <span class="text-smallcaps">L</span>-folinate
• Calcium Folinate
• Calcium Folinate(Folinic Acid)(Rg)
• Calcium L-Folinate
• Calcium leucovorin
• Calcium2-[4-[(2-Amino-5-Formyl-4-Oxo-1,6,7,8-Tetrahydropteridin-6-Yl)Methylamino]Benzoyl] Aminopentanedioate
• Calciumfolinat
• Folidan
• Folinate De Calcium
• Folinate-SF calcium
• Folinato Calcico
• Folinic acid Calcium salt
• Folinic acid calcium salt USP28
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1), L-
• L-Calcium Folinate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, calcium salt (1:1)
• Lederfoline
• Leucovorin Calcium
• Leucovorin calcium salt
• LeucovorinCalcium
• Leucovorine calcium
• Nsc 3590
• Rescuvolin
• Wellcovorin
• calcium (2S)-2-({[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}amino)pentanedioate
• calcium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)amino]pentanedioate

Calcium folinate

CAS: 1492-18-8

Dihydrofolate reductase activator; decreases methotrexate toxicity

• Formula: C₂₀H₂₁CaN₇O₇
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 511.50 g/mol

Calcium folinate for system suitability CRS

CAS: 1492-18-8

Folic Acid Related Compound A (Calcium Formyltetrahydrofolate) (DISCONTINUED)

CAS: 1492-18-8

Other vitamins and their derivatives, nesoi

• Formula: C₂₀H₂₃N₇O₇·Ca
• Color and Shape: Powder
• Molecular weight: 513.12849