CAS 149249-72-9

Dorzolamide

Description:

Dorzolamide is a carbonic anhydrase inhibitor primarily used in the treatment of elevated intraocular pressure in conditions such as glaucoma and ocular hypertension. It is a white to off-white crystalline powder that is soluble in water and exhibits a pH range of approximately 5.5 to 7.5 in solution. The molecular formula of dorzolamide is C10H16N2O4S, and it has a molecular weight of around 224.31 g/mol. The compound works by inhibiting the enzyme carbonic anhydrase, which reduces the production of aqueous humor in the eye, thereby lowering intraocular pressure. Dorzolamide is typically administered as an eye drop solution and may be used alone or in combination with other medications. Its pharmacokinetics indicate that it has a relatively short half-life, necessitating multiple daily doses for effective management of eye pressure. Side effects may include ocular discomfort, taste alterations, and potential allergic reactions, making patient monitoring essential during treatment.

Formula: C₁₀H₁₆N₂O₄S₃

InChI: InChI=1/C10H18N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-8,10,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,7?,8-,10?/m0/s1

SMILES: CCN[C@H]1C[C@H](C)S(=O)(=O)C2C1C=C(S2)S(=O)(=O)N

Synonyms:

• (2R,4R)-2-Ethylamino-4-Methyl-5,5-Dioxo-5,7-Dithiabicyclo[4.3.0]Nona-8,10-Diene-8-Sulfonamide
• Dorzolamide(Subjecttopatentfree)
• 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
• 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-trans)-
• 4S,6S-Dorzolamide
• (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,
• 4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
• (4R,6R)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
• (4S,6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
• 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-cis)-
• 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4R-cis)-
• Dorzolamide Impurity B
• 5,6-dihydro-(s)-4-(ethylamino)-(s)-6-methyl-4h-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
• 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4R,6S)-

(4R,6S)-Dorzolamide EP Impurity B

CAS: 149249-72-9

Formula: C₁₀H₁₆N₂O₄S₃

Color and Shape: White To Off-White Solid

Molecular weight: 324.43

Ref: 4Z-D-6446

(4R)-Dorzolamide-d5

Controlled Product

CAS: 149249-72-9

Formula: C₁₀H₁₁D₅N₂O₄S₃

Color and Shape: Neat

Molecular weight: 329.47

Ref: TR-D535152

(4R)-Dorzolamide

Controlled Product

CAS: 149249-72-9

Formula: C₁₀H₁₆N₂O₄S₃

Color and Shape: Neat

Molecular weight: 324.44

Ref: TR-D535150

(4R)-Dorzolamide

CAS: 149249-72-9

(4R)-Dorzolamide is a medicinal compound that acts as an inhibitor of kinases, a class of proteins that play important roles in cellular signaling pathways. This compound has been shown to be effective in inhibiting the growth of cancer cells in Chinese hamster ovary cells and human tumor cell lines. (4R)-Dorzolamide is an analog of other anticancer inhibitors, such as imatinib, and has been shown to induce apoptosis, or programmed cell death, in cancer cells. Additionally, this compound has been found in urine samples from patients receiving treatment for cancer, indicating its potential use as a diagnostic tool for detecting cancer. Overall, (4R)-Dorzolamide shows great promise as a potential anticancer agent with significant therapeutic potential.

Formula: C₁₀H₁₆N₂O₄S₃

Purity: Min. 95%

Molecular weight: 324.4 g/mol

Ref: 3D-ZFA24972

Dorzolamide Impurity 6

CAS: 149249-72-9

Formula: C₁₀H₁₆N₂O₄S₃

Molecular weight: 324.4

Ref: ST-EA-CP-D25016