CAS 14930-96-2

Cytochalasin B

Description:

Cytochalasin B is a naturally occurring alkaloid derived from various species of fungi, particularly from the genus *Helminthosporium*. It is known for its ability to inhibit actin polymerization, which disrupts cytoskeletal dynamics and affects cell motility, division, and shape. This compound has a molecular formula of C_22H_29N_3O_5 and features a complex structure that includes a lactone ring and multiple functional groups. Cytochalasin B is often used in biological research to study cellular processes, particularly in the fields of cell biology and pharmacology. Its mechanism of action involves binding to the barbed end of actin filaments, preventing their elongation. Additionally, it has been investigated for potential therapeutic applications, although its use is primarily limited to laboratory settings due to its cytotoxic effects. Safety precautions are necessary when handling Cytochalasin B, as it can have significant effects on cellular functions and may pose health risks if not managed properly.

Formula:C₂₉H₃₇NO₅

InChI:InChI=1/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22+,23+,24?,26?,27-,29-/m1/s1

InChI key:InChIKey=GBOGMAARMMDZGR-TYHYBEHESA-N

SMILES:O=C1[C@]23[C@]([C@H](CC4=CC=CC=C4)N1)([C@H](C)C(=C)[C@@H](O)[C@@]2(/C=C/C[C@H](C)CCC[C@@H](O)\C=C\C(=O)O3)[H])[H]

Synonyms:

(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
(3E,5S,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
(3E,5S,9R,11E,12aS,13S,15S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
(E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione
10-fenil-7(S),20(R)-dihidroxi-16(R)-metil-24-oxa[14]citochalasa-6(12),13(E),21(E)-trieno-1,23-diona
16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione
24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-
2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E)-(5S,9R,12aS,13S,15S,15aS,16aS,18aS)-
2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-
2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-
2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5R,9R,12aS,13S,15S,15aS,16S,18aS)-
2H-Oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, [5R-(3E,5R*,9R*,11E,12aS*,13S*,15S*,15aS*,16S*,18aS*)]-
7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-trien-1,23-dion
7,20-Dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-(14)cytochalas-6(12),13,21-trien-23-one
Brn 1096207
Ccris 9284
Hsdb 3479
Nsc 107658
Phomin
Cytochalasin B
CYTOCHALASIN B SYNTHETIC >97%
2h-oxacyclotetradec(2,3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13
(7s,13e,16r,20r,21e)-0-phenyl
CYTOCHALICINB
cytochalasin
CYTOCHALACINB
cytochalasin b from drechslera dematioidea
,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e)-(
9r,12as,13s,15s,15as,16as,18as)-5
7,20-dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-[14]cytochalas-6(12),13,21-trien
,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2h-oxacyclotetrad
CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM
CytochalasinB from Drechslera dematioidea,Phomin
(E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE
9r,12as,13s,15s,15as,16s,18as)--(5
Cytochalasin B, froM Drechslera deMatoidea
Cytochalasin beta,helminthosporium dematioideum
CYTOCHALASIN B FROM HELMINTHOSPORIUM DEMATIODEUM
Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
CYTOCHALASIN B(RG)
CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 95.0% (HPLC)
,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-,(e,e)
CYTOCHALASIN B FROM DRESCHSLERA DEMATIOIDEA
3-d)isoindole-2,18(5h)-dione,16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-2h-oxacyclotetradec(
(e,e)-(5s,9r,12as,13s,15s,15as,16s,18as)-16-benzyl-6,7,8,9,10,12a,13,14,15,15a
24-oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione,7,20-dihydroxy-16-methyl-1
(7S,13E,16R,20R,21E)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,23-dione
ec[2,3-d]isoindole-2,18(5h)-dione
(7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione
Cytochalasin B from Helminthosporium dematioideum
See more synonyms

Purity (%)

100

Found 7 products.

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Cytochalasin B
CAS:
- 14930-96-2
An actin-disrupting agent
Formula:C₂₉H₃₇NO₅
Color and Shape:Powder
Molecular weight:479.61
Ref: 02-J65342
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Cytochalasin B
CAS:
- 14930-96-2
Cytochalasin B
Formula:C₂₉H₃₇NO₅
Purity:By hplc: 99.35% (Typical Value in Batch COA)
Color and Shape: white powder
Molecular weight:479.60777g/mol
Ref: 54-BIC1014
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Cytochalasin B
CAS:
- 14930-96-2
Formula:C₂₉H₃₇NO₅
Purity:95%~99%
Molecular weight:479.617
Ref: BP-SBP03783
ne
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Cytochalasin B
CAS:
- 14930-96-2
Formula:C₂₉H₃₇NO₅
Purity:(HPLC) ≥ 97.0%
Color and Shape:White to off-white powder
Molecular weight:479.61
Ref: 7W-GA2080
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Cytochalasin B
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 14930-96-2
Applications Cytochalasin B is a fungal metabolic toxin that preferentially damages malignant cells. Microfilament-disrupting agent which inhibites cytokinesis and produces enlarged neoplastic cells. Apoptotic agent. References Trendowski, M. et al.: Anticanc. Res., 35, 65 (2015); 
Formula:C₂₉H₃₅N₀₅
Color and Shape:Neat
Molecular weight:477.60
Ref: TR-C998680
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Cytochalasin B
CAS:
- 14930-96-2
Blocker of the actin monomers to the actin filament
Formula:C₂₉H₃₇NO₅
Purity:Min. 95%
Color and Shape:White/Off-White Solid
Molecular weight:479.61 g/mol
Ref: 3D-FC11288
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Cytochalasin B
CAS:
- 14930-96-2
Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).
Formula:C₂₉H₃₇NO₅
Purity:98.79% - ＞99.99%
Color and Shape:Felted Needles From Acetone Powder
Molecular weight:479.61
Ref: TM-T7097