CAS 149385-65-9

amyloid B-protein fragment 31-35*acetate

Description:

Amyloid beta-protein fragment 31-35 acetate, identified by its CAS number 149385-65-9, is a peptide that is a truncated form of the amyloid beta protein, which is associated with Alzheimer's disease. This fragment consists of five amino acids and is known for its role in the aggregation process that leads to amyloid plaque formation in the brains of individuals with Alzheimer's. The acetate modification enhances its solubility and stability, making it useful for research purposes. Characteristically, this peptide can exhibit neurotoxic effects, influencing neuronal health and function. It is often studied in the context of neurodegenerative diseases to understand its interactions with other biomolecules and its impact on cellular pathways. The fragment's small size allows for easy synthesis and manipulation in laboratory settings, facilitating investigations into its biological activity and potential therapeutic implications. Overall, amyloid beta-protein fragment 31-35 acetate serves as a significant model for studying the molecular mechanisms underlying amyloid pathology.

Formula: C₂₅H₄₇N₅O₆S

Synonyms:

• H-Ile-Ile-Gly-Leu-Met-Oh

Amyloid β-Protein (31-35)

CAS: 149385-65-9

The neurotoxicity of the short fragment IIGLM is similar to that of amyloid β-protein (1-42). Aβ 31-35 induced apoptosis in undifferentiated PC 12 cells.

Formula: C₂₅H₄₇N₅O₆S

Purity: 98.5%

Color and Shape: White Powder

Molecular weight: 545.74

Ref: 01-4041418

β-Amyloid (31-35)

CAS: 149385-65-9

β-Amyloid (31-35)

Purity: ≥98%

Molecular weight: 545.74g/mol

Ref: 54-BUP02537

β-Amyloid (31-35)

CAS: 149385-65-9

β-Amyloid (31-35) (β-Amyloid 31-35) is the shortest sequence of native Amyloid-β peptide.

Formula: C₂₅H₄₇N₅O₆S

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 545.74

Ref: TM-T7562

Amyloid beta-Protein (31-35)

CAS: 149385-65-9

Amyloid beta protein is a peptide that is a major component of the amyloid plaques found in the brain of patients with Alzheimer's disease. Amyloid beta protein (Aβ) has been shown to form fibers and fibrils, which are aggregates of polymerized Aβ peptides. These fibrils can be imaged using a fluorescent dye called dansyl. The dansyl-labeled Aβ fibrils have been shown to have a morphology similar to that seen in electron micrographs of amyloid plaques. The quantum yield for luminescence was found to be 0.1% for the Aβ fibrils but only 0.001% for the monomeric form of Aβ peptides (Aβ 1-40). This suggests that the Aβ peptides are undergoing aggregation into amyloid beta protein fibrils before they can emit light as fluorescence or phosphorescence.

Formula: C₂₅H₄₇N₅O₆S

Purity: Min. 95%

Molecular weight: 545.74 g/mol

Ref: 3D-FA109633