CAS 149503-79-7

Lefradafiban

Description:

Lefradafiban is a synthetic chemical compound classified as a glycoprotein IIb/IIIa receptor antagonist, primarily used in the context of cardiovascular medicine. It functions by inhibiting platelet aggregation, thereby reducing the risk of thrombus formation in patients with acute coronary syndromes. The compound is characterized by its ability to selectively bind to the glycoprotein IIb/IIIa receptor on platelets, which plays a crucial role in the final common pathway of platelet activation. Lefradafiban has been investigated for its potential in improving outcomes in patients undergoing percutaneous coronary interventions. Its pharmacokinetic profile includes rapid absorption and a relatively short half-life, necessitating careful dosing and monitoring during clinical use. As with many antiplatelet agents, potential side effects may include bleeding complications, which require consideration in patient management. Overall, Lefradafiban represents a significant advancement in antiplatelet therapy, contributing to the broader category of drugs aimed at preventing thrombotic events in high-risk populations.

Formula: C₂₃H₂₅N₃O₆

InChI: InChI=1S/C23H25N3O6/c1-30-20(27)12-17-11-18(25-22(17)28)13-32-19-9-7-15(8-10-19)14-3-5-16(6-4-14)21(24)26-23(29)31-2/h3-10,17-18H,11-13H2,1-2H3,(H,25,28)(H2,24,26,29)/t17-,18-/m0/s1

InChI key: InChIKey=PGCFXITVMNNKON-ROUUACIJSA-N

SMILES: C(NC(OC)=O)(=N)C1=CC=C(C=C1)C2=CC=C(OC[C@@H]3C[C@@H](CC(OC)=O)C(=O)N3)C=C2

Synonyms:

• 3-Pyrrolidineacetic acid, 5-[[[4′-[imino[(methoxycarbonyl)amino]methyl][1,1′-biphenyl]-4-yl]oxy]methyl]-2-oxo-, methyl ester, (3S,5S)-
• methyl {(3S,5S)-5-[({4'-[N'-(methoxycarbonyl)carbamimidoyl]biphenyl-4-yl}oxy)methyl]-2-oxopyrrolidin-3-yl}acetate
• BIBU 104XX
• 3-Pyrrolidineacetic acid, 5-[[[4′-[imino[(methoxycarbonyl)amino]methyl][1,1′-biphenyl]-4-yl]oxy]methyl]-2-oxo-, methyl ester, (3S-trans)-
• Lefradafiban

Lefradafiban

CAS: 149503-79-7

Lefradafiban

Purity: ≥95%

Molecular weight: 439.46g/mol

Ref: 54-BUP03145

Lefradafiban

CAS: 149503-79-7

Lefradafiban（BIBU-104） is an oral platelet glycoprotein IIb/IIIa receptor antagonist for the study of angina pectoris and acute coronary syndromes.

Formula: C₂₃H₂₅N₃O₆

Purity: 97.26% - 98.92%

Color and Shape: Solid

Molecular weight: 439.46

Ref: TM-T27808