CAS 149647-78-9: Vorinostat
Description:Vorinostat, also known by its chemical name suberoylanilide hydroxamic acid (SAHA), is a histone deacetylase (HDAC) inhibitor used primarily in cancer therapy. It is classified as an antineoplastic agent and is particularly effective in treating cutaneous T-cell lymphoma (CTCL). Vorinostat works by altering the expression of genes involved in cell cycle regulation and apoptosis, leading to the induction of cell differentiation and death in cancer cells. The compound is characterized by its hydroxamic acid functional group, which is crucial for its HDAC inhibitory activity. Vorinostat is typically administered orally and is known for its side effects, which may include fatigue, gastrointestinal disturbances, and hematological changes. Its pharmacokinetics involve extensive metabolism, primarily in the liver, and it has a relatively short half-life. Vorinostat's development marked a significant advancement in epigenetic therapy, highlighting the potential of targeting histone modifications in cancer treatment.
Formula:C14H20N2O3
InChI:InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChI key:InChIKey=WAEXFXRVDQXREF-UHFFFAOYSA-N
SMILES:O=C(NO)CCCCCCC(=O)NC=1C=CC=CC1
- Synonyms:
- Ccris 8456
- M344
- N-Hydroxy-N'-phenyloctanediamide
- N-Hyrdroxy-N'-phenyloctanediamide
- N<sup>1</sup>-Hydroxy-N<sup>8</sup>-phenyloctanediamide
- Octanediamide, N-hydroxy-N'-phenyl-
- Octanediamide, N<sup>1</sup>-hydroxy-N<sup>8</sup>-phenyl-
- SAHA cpd
- Suberanilohydroxamic acid
- Suberoyl anilide bishydroxamide
- See more synonyms
- Suberoylanilide Hydroxamic Acid
- Unii-58Ifb293Ji
- Vorinostat [USAN]
- Wt 171
- Zolinza
- Octanediamide, N1-hydroxy-N8-phenyl-
- SAHA
- N1-Hydroxy-N8-phenyloctanediamide
