CAS 149647-78-9

Vorinostat

Description:

Vorinostat, also known by its chemical name suberoylanilide hydroxamic acid (SAHA), is a histone deacetylase (HDAC) inhibitor used primarily in cancer therapy. It is classified as an antineoplastic agent and is particularly effective in treating cutaneous T-cell lymphoma (CTCL). Vorinostat works by altering the expression of genes involved in cell cycle regulation and apoptosis, leading to the induction of cell differentiation and death in cancer cells. The compound is characterized by its hydroxamic acid functional group, which is crucial for its HDAC inhibitory activity. Vorinostat is typically administered orally and is known for its side effects, which may include fatigue, gastrointestinal disturbances, and hematological changes. Its pharmacokinetics involve extensive metabolism, primarily in the liver, and it has a relatively short half-life. Vorinostat's development marked a significant advancement in epigenetic therapy, highlighting the potential of targeting histone modifications in cancer treatment.

Formula: C₁₄H₂₀N₂O₃

InChI: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

InChI key: InChIKey=WAEXFXRVDQXREF-UHFFFAOYSA-N

SMILES: N(C(CCCCCCC(NO)=O)=O)C1=CC=CC=C1

Synonyms:

• Ccris 8456
• M344
• N-Hydroxy-N'-phenyloctanediamide
• N-Hyrdroxy-N'-phenyloctanediamide
• N¹-Hydroxy-N⁸-phenyloctanediamide
• Octanediamide, N-hydroxy-N'-phenyl-
• Octanediamide, N¹-hydroxy-N⁸-phenyl-
• SAHA cpd
• Suberanilohydroxamic acid
• Suberoyl anilide bishydroxamide
• Suberoylanilide Hydroxamic Acid
• Unii-58Ifb293Ji
• Vorinostat [USAN]
• Wt 171
• Zolinza
• Octanediamide, N1-hydroxy-N8-phenyl-
• SAHA

N-Hydroxy-N'-phenyloctanediamide

CAS: 149647-78-9

Formula: C₁₄H₂₀N₂O₃

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 264.33

Ref: 3B-H1388

N-Hydroxy-N'-phenyloctanediamide

CAS: 149647-78-9

Formula: C₁₄H₂₀N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 264.3202

Ref: IN-DA00382H

Vorinostat

CAS: 149647-78-9

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11.

Formula: C₁₄H₂₀N₂O₃

Purity: 99.47% - 99.65%

Color and Shape: White Crystalline Solid

Molecular weight: 264.32

Ref: TM-T1583

Vorinostat

CAS: 149647-78-9

Formula: C₁₄H₂₀N₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 264.33

Ref: 4Z-V-071

Vorinostat-d5

CAS: 149647-78-9

Formula: C₁₄H₂₀N₂O₃

Molecular weight: 269.36

Ref: 4Z-V-072

N-Hydroxy-N'-Phenyloctanediamide

CAS: 149647-78-9

N-Hydroxy-N'-Phenyloctanediamide

Purity: 99%

Molecular weight: 264.32g/mol

Ref: 54-OR1014396

Vorinostat

CAS: 149647-78-9

Vorinostat

Purity: ≥98%

Molecular weight: 264.32g/mol

Ref: 54-BUP17865

Vorinostat

Controlled Product

CAS: 149647-78-9

Formula: C₁₄H₂₀N₂O₃

Color and Shape: Neat

Molecular weight: 264.32

Ref: 86-MM3699.00

Vorinostat

CAS: 149647-78-9

Formula: C₁₄H₂₀N₂O₃

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 264.32

Ref: 7W-GP5178

Vorinostat-13C6

CAS: 149647-78-9

Formula: C₆C₈H₂₀N₂O₃

Molecular weight: 270.28

Ref: 4Z-V-079

Suberoylanilide Hydroxamic Acid

Controlled Product

CAS: 149647-78-9

Formula: C₁₄H₂₀N₂O₃

Color and Shape: White Solid

Molecular weight: 264.32

Ref: TR-S688700

Vorinostat

CAS: 149647-78-9

M06303 - Vorinostat

Formula: C₁₄H₂₀N₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 264.325

Ref: 10-M06303

Vorinostat

CAS: 149647-78-9

Vorinostat is a histone deacetylase inhibitor which interferes with gene transcription regulatory mechanisms. It targets histones and non-histone proteins within transcription factor complexes involved in regulation of cell proliferation (p53), protein stability (Hsp90), apoptosis (Bcl-2 family), cell motility (α-tublin), and angiogenesis (HIF-1α). Vorinostat affects epigenetic regulation in various cancers and has been used in clinical trials as anticancer drug.

Formula: C₁₄H₂₀N₂O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 264.32 g/mol

Ref: 3D-FH15949

Vorinostat - Bio-X ™

CAS: 149647-78-9

Vorinostat is a histone deacetylase inhibitor which interferes with gene transcription regulatory mechanisms. It is used to treat cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. This drug inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II).

Formula: C₁₄H₂₀N₂O₃

Purity: Min. 99 Area-%

Color and Shape: Powder

Molecular weight: 264.32 g/mol

Ref: 3D-BV164560

Suberoylanilide Hydroxamic Acid-13C6

Controlled Product

CAS: 149647-78-9

Applications is the labeled form of Suberoylanilide Hydroxamic Acid (S688700), which is a potent, selective, cell permeable histone deacetylase inhibitor (HDAC), displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs) and induces differentiation in human breast cancer cells. Also it is a potent histone deacetylase inhibitor.
References Richon, V.M., et al.: Proc. Natl. Acad.Sci. USA, 95, 3003 (1988), Munster, P.N., et al.: Cancer Res., 61, 8492 (2001), Deroanne, C.F., et al.: Oncogene, 21, 247 (2002)

Formula: C₆C₈H₂₀N₂O₃

Color and Shape: Neat

Molecular weight: 270.276

Ref: TR-S688704