CAS 1496510-51-0

[(4aR)-1-(4-Fluorophenyl)-1,4,5,6,7,8-hexahydro-6-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)-2-pyridinyl]methanone

Description:

The chemical substance with the name "[(4aR)-1-(4-Fluorophenyl)-1,4,5,6,7,8-hexahydro-6-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)-2-pyridinyl]methanone" and CAS number "1496510-51-0" is a complex organic compound characterized by its multi-cyclic structure and the presence of various functional groups. It features a hexahydroisoquinoline framework, which contributes to its potential biological activity. The presence of a fluorophenyl group and a trifluoromethyl-pyridine moiety suggests that it may exhibit significant lipophilicity, potentially influencing its pharmacokinetic properties. Additionally, the sulfonyl group attached to a pyrazole ring may enhance its reactivity and interaction with biological targets. This compound is likely to be of interest in medicinal chemistry, particularly for its potential therapeutic applications, although specific biological activities and mechanisms would require further investigation. Overall, its structural complexity and functional diversity make it a candidate for research in drug development and related fields.

Formula: C₂₇H₂₂F₄N₆O₃S

InChI: InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1

InChI key: InChIKey=WANIDIGFXJFFEL-SANMLTNESA-N

SMILES: C(=O)([C@@]12C(=CC3=C(C1)C=NN3C4=CC=C(F)C=C4)CCN(S(=O)(=O)C5=CN(C)N=C5)C2)C6=CC(C(F)(F)F)=CC=N6

Synonyms:

• [(4aR)-1-(4-Fluorophenyl)-1,4,5,6,7,8-hexahydro-6-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)-2-pyridinyl]methanone
• [(4aR)-1-(4-fluorophenyl)-6-(1-methyl-1H-pyrazole-4-sulfonyl)-1,4,5,6,7,8hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin-2-yl]methanone
• Relacorilant
• Methanone, [(4aR)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-6-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)-2-pyridinyl]-
• CORT 125134
• [(4aR)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone
• EOS-61931
• (R)-(1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone

Relacorilant

CAS: 1496510-51-0

Relacorilant

Purity: ≥98%

Molecular weight: 586.56g/mol

Ref: 54-BUP20874

Relacorilant

CAS: 1496510-51-0

Relacorilant is a drug that inhibits the production of epidermal growth factor (EGF). This drug has been shown to be effective in the treatment of adrenocortical carcinoma. Relacorilant is given to patients in a dose-dependent manner, with low doses being more effective than high doses. Relacorilant has been shown to have an anti-tumor effect in vitro and in vivo, which may be due to its inhibition of EGFR activity on cell signaling pathways.

Formula: C₂₇H₂₂F₄N₆O₃S

Purity: Min. 95%

Molecular weight: 586.6 g/mol

Ref: 3D-WJC51051

Relacorilant

CAS: 1496510-51-0

Relacorilant is an oral glucocorticoid receptor antagonist with Ki of 7.2 nM, potential for treating Cushing's syndrome.

Formula: C₂₇H₂₂F₄N₆O₃S

Purity: 98.53% - 99%

Color and Shape: Solid

Molecular weight: 586.56

Ref: TM-T16727