CAS 149682-77-9

Talabostat

Description:

Talabostat, with the CAS number 149682-77-9, is a small molecule that functions primarily as a dual inhibitor of the enzymes dipeptidyl peptidase I (DPP I) and dipeptidyl peptidase IV (DPP IV). It is notable for its role in modulating immune responses and has been investigated for its potential therapeutic applications in cancer and autoimmune diseases. Talabostat is characterized by its ability to enhance the activation and proliferation of T cells, thereby promoting anti-tumor immunity. The compound has also been studied for its effects on the tumor microenvironment, potentially leading to increased efficacy of other therapeutic agents. In terms of its chemical properties, Talabostat is a synthetic compound with a specific molecular structure that contributes to its biological activity. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are important factors in its therapeutic potential and safety profile. Overall, Talabostat represents a promising avenue for research in immunotherapy and cancer treatment.

Formula: C₉H₁₉BN₂O₃

InChI: InChI=1S/C9H19BN2O3/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15/h6-8,14-15H,3-5,11H2,1-2H3/t7-,8-/m0/s1

InChI key: InChIKey=FKCMADOPPWWGNZ-YUMQZZPRSA-N

SMILES: C([C@H](C(C)C)N)(=O)N1[C@H](B(O)O)CCC1

Synonyms:

• Boronic acid, [(2R)-1-[(2S)-2-amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-
• PT 100
• Boronic acid, [1-(2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl]-, [R-(R*,S*)]-
• Talabostat
• [(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid

Talabostat

CAS: 149682-77-9

Formula: C₉H₁₉BN₂O₃

Molecular weight: 214.0698

Ref: IN-DA00AOWA

Talabostat

CAS: 149682-77-9

Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM.

Formula: C₉H₁₉BN₂O₃

Color and Shape: Solid

Molecular weight: 214.07

Ref: TM-T37861

Talabostat

CAS: 149682-77-9

Talabostat is a small-molecule inhibitor, specifically targeting dipeptidyl peptidase (DPP) enzymes. It is a synthetic compound designed to inhibit these serine proteases, which are known to play critical roles in tumor growth and metastasis by affecting the tumor microenvironment. The primary mode of action of Talabostat involves the irreversible inhibition of DPP IV and related enzymes, disrupting key signaling pathways that facilitate cancer cell proliferation and immune evasion.

Formula: C₉H₁₉BN₂O₃

Purity: Min. 95%

Molecular weight: 214.07 g/mol

Ref: 3D-ZFA68277