CAS 149690-12-0

[1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride (1:1), (αR,γS)-

Description:

[1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride (1:1), (αR,γS)- is a chemical compound characterized by its biphenyl structure, which consists of two phenyl rings connected by a single bond. This compound features a pentanoic acid moiety, indicating the presence of a five-carbon chain with a carboxylic acid functional group, along with an amino group that contributes to its basicity. The ethyl ester form suggests that the carboxylic acid is esterified with an ethyl group, enhancing its lipophilicity and potentially influencing its biological activity. The hydrochloride salt form indicates that the compound is protonated, which can improve its solubility in aqueous environments. The stereochemistry is specified as (αR,γS), indicating the specific three-dimensional arrangement of atoms around the chiral centers, which can significantly affect the compound's pharmacological properties. Overall, this compound may have applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways.

Formula: C₂₀H₂₅NO₂·ClH

InChI: InChI=1S/C20H25NO2.ClH/c1-3-23-20(22)15(2)13-19(21)14-16-9-11-18(12-10-16)17-7-5-4-6-8-17;/h4-12,15,19H,3,13-14,21H2,1-2H3;1H/t15-,19+;/m1./s1

InChI key: InChIKey=MYJTZLYRAWUSLB-WSCVZUBPSA-N

SMILES: C([C@H](C[C@H](C(OCC)=O)C)N)C1=CC=C(C=C1)C2=CC=CC=C2.Cl

Synonyms:

• (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methyl pentanoic acid ethyl ester hydrochloride
• (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride
• Ethyl (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
• [1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride (1:1), (αR,γS)-
• [1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride, [S-(R*,S*)]-
• (2R,4S)-Ethyl-5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride

(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate HCl salt

CAS: 149690-12-0

Formula: C₂₀H₂₆ClNO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 347.8789

Ref: IN-DA00ANEL

(2R,4S)-Ethyl 5-([1,1’-Biphenyl]-4-Yl)-4-Amino-2-Methylpentanoate Hydrochloride

CAS: 149690-12-0

(2R,4S)-Ethyl 5-([1,1’-Biphenyl]-4-Yl)-4-Amino-2-Methylpentanoate Hydrochloride

Purity: 98%

Molecular weight: 347.88g/mol

Ref: 54-OR1007995

Sacubitril Impurity 9 HCl

CAS: 149690-12-0

Formula: C₂₀H₂₅NO₂·HCl

Color and Shape: White To Off-White Solid

Molecular weight: 311.43 36.46

Ref: 4Z-S-072016

Sacubitril Impurity 9

CAS: 149690-12-0

Formula: C₂₀H₂₅NO₂HCl

Molecular weight: 311.4 : 36.5

Ref: ST-EA-CP-S18010

N-des-succinyl-Sacubitril hydrochloride

Controlled Product

CAS: 149690-12-0

Applications (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.
References Liu, M., et al.: Faming Zhuanli Shenqing. CN 105168205 A 20151223. Dec 23, 2015; Wang, Z.: PCT Int. Appl. WO 2015154673 A1 20151015. Oct 15, 2015

Formula: C₂₀H₂₅NO₂·HCl

Color and Shape: Neat

Molecular weight: 384.34

Ref: TR-A601540

(2R,4S)-ETHYL 5-([1,1′-BIPHENYL]-4-YL)-4-AMINO-2-METHYLPENTANOATE HCL

CAS: 149690-12-0

Formula: C₂₀H₂₆ClNO₂

Purity: 98%

Molecular weight: 347.88

Ref: 10-F512686

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride

CAS: 149690-12-0

Versatile small molecule scaffold

Formula: C₂₀H₂₅NO₂•HCl

Purity: Min. 95%

Molecular weight: 347.88 g/mol

Ref: 3D-ZFA69012

(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride

CAS: 149690-12-0

(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66599 and the CAS number is 149690-12-0.

Formula: C₂₀H₂₆ClNO₂

Color and Shape: Solid

Molecular weight: 347.88

Ref: TM-T66599