CAS 149709-62-6

Sacubitril

Description:

Sacubitril is a pharmaceutical compound primarily used in the treatment of heart failure. It functions as a neprilysin inhibitor, which enhances the levels of natriuretic peptides, leading to vasodilation and reduced blood pressure. The chemical structure of sacubitril includes a carboxylate group and a sulfonamide moiety, contributing to its biological activity. It is typically administered in combination with valsartan, an angiotensin receptor blocker, to provide a synergistic effect in managing heart failure. Sacubitril is characterized by its moderate solubility in water and its stability under physiological conditions. The compound is metabolized in the liver, primarily by esterases, to its active metabolite, which exerts the therapeutic effects. Its pharmacokinetics involve a relatively short half-life, necessitating twice-daily dosing. Common side effects may include hypotension, hyperkalemia, and renal impairment, necessitating monitoring during treatment. Overall, sacubitril represents a significant advancement in heart failure management, offering a novel mechanism of action that improves patient outcomes.

Formula: C₂₄H₂₉NO₅

InChI: InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1

InChI key: InChIKey=PYNXFZCZUAOOQC-UTKZUKDTSA-N

SMILES: C([C@H](C[C@H](C(OCC)=O)C)NC(CCC(O)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2

Synonyms:

• (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester
• (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester
• AHU377 Free acid
• Ahu-377
• Ahu377
• Sacubitril
• [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, ethyl ester, [S-(R*,S*)]-
• [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αR,γS)-

3-{[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]carbamoyl}propanoic acid

CAS: 149709-62-6

Formula: C₂₄H₂₉NO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 411.4908

Ref: IN-DA001LYG

Sacubitril

CAS: 149709-62-6

Formula: C₂₄H₂₉NO₅

Color and Shape: Pale Yellow Clear Semi-Solid

Molecular weight: 411.50

Ref: 4Z-S-072001

Sacubitril

CAS: 149709-62-6

Sacubitril

Purity: ≥90%

Molecular weight: 411.49g/mol

Ref: 54-BUP15439

Sacubitril

CAS: 149709-62-6

Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696.

Formula: C₂₄H₂₉NO₅

Purity: 97.72% - 97.91%

Color and Shape: Solid

Molecular weight: 411.49

Ref: TM-T4574

Sacubitril

CAS: 149709-62-6

Formula: C₂₄H₂₉NO₅

Color and Shape: Off-White To Light Yellow

Molecular weight: 411.49

Ref: TR-S080895

Sacubitril

CAS: 149709-62-6

Formula: C₂₄H₂₉NO₅

Molecular weight: 411.50

Ref: ST-EA-CP-S18000

Sacubitril - Bio-X ™

CAS: 149709-62-6

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₄H₂₉NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 411.49 g/mol

Ref: 3D-FB71505

Sacubitril

CAS: 149709-62-6

Please enquire for more information about Sacubitril including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₂₄H₂₉NO₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 411.49 g/mol

Ref: 3D-FS183789

Sacubitril

CAS: 149709-62-6

Purity: 98%

Molecular weight: 411.4979858

Ref: 10-F869342