CAS 149709-62-6: Sacubitril
Description:Sacubitril is a pharmaceutical compound primarily used in the treatment of heart failure. It functions as a neprilysin inhibitor, which enhances the levels of natriuretic peptides, leading to vasodilation and reduced blood pressure. The chemical structure of sacubitril includes a carboxylate group and a sulfonamide moiety, contributing to its biological activity. It is typically administered in combination with valsartan, an angiotensin receptor blocker, to provide a synergistic effect in managing heart failure. Sacubitril is characterized by its moderate solubility in water and its stability under physiological conditions. The compound is metabolized in the liver, primarily by esterases, to its active metabolite, which exerts the therapeutic effects. Its pharmacokinetics involve a relatively short half-life, necessitating twice-daily dosing. Common side effects may include hypotension, hyperkalemia, and renal impairment, necessitating monitoring during treatment. Overall, sacubitril represents a significant advancement in heart failure management, offering a novel mechanism of action that improves patient outcomes.
Formula:C24H29NO5
InChI:InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
InChI key:InChIKey=PYNXFZCZUAOOQC-UTKZUKDTSA-N
SMILES:O=C(O)CCC(=O)NC(CC=1C=CC(=CC1)C=2C=CC=CC2)CC(C(=O)OCC)C
- Synonyms:
- (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester
- (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester
- AHU377 Free acid
- Ahu-377
- Ahu377
- Sacubitril
- [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, ethyl ester, [S-(R*,S*)]-
- [1,1′-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αR,γS)-
![[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, α-ethyl ester, (αR,γ…](https://static.cymitquimica.com/products/IN/thumb/DA001LYG.jpg)
