CAS 14976-57-9: Clemastine fumarate
Description:Clemastine fumarate is an antihistamine medication primarily used to relieve allergy symptoms, such as runny nose, sneezing, and itching. It is classified as a first-generation antihistamine, which means it can cross the blood-brain barrier, often leading to sedative effects. The substance is a salt formed from clemastine, a diphenylmethanol derivative, and fumaric acid. In its pure form, clemastine fumarate appears as a white to off-white crystalline powder, which is soluble in water and alcohol. Its mechanism of action involves antagonizing the H1 histamine receptors, thereby inhibiting the effects of histamine, a compound involved in allergic responses. Additionally, clemastine fumarate may exhibit anticholinergic properties, contributing to its efficacy in alleviating symptoms. The compound is typically administered orally and is available in various formulations, including tablets and syrups. As with many antihistamines, potential side effects may include drowsiness, dry mouth, and dizziness, necessitating caution when driving or operating heavy machinery.
Formula:C21H26ClNO·C4H4O4
InChI:InChI=1/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
SMILES:O=C(O)C=CC(=O)O.ClC1=CC=C(C=C1)C(OCCC2N(C)CCC2)(C=3C=CC=CC3)C
- Synonyms:
- (+)-(2R)-2-[2-[[(R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
- (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate
- (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy)]Ethyl]-1-Methyl-2-Pyrrolidine Fumarate
- (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine
- (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine (2E)-but-2-enedioate
- 2-{2-[1-(4-Chlorophenyl)-1-Phenylethoxy]Ethyl}-1-Methylpyrrolidine
- Agasten
- Aloginan
- Alphamin
- Anhistan
- See more synonyms
- Bravegyl
- Clemastine
- Clemastine Fumarate Salt
- Clemastine Hydrogen Fumarate
- Clemastinum
- Fuluminol
- Hs 592
- Inbestan
- Kinotomin
- Lacretin
- Lecasol
- Maikohis
- Mallermin F
- Marsthine
- Masletine
- Meclastine fumarate
- Mecloprodine
- Piloral
- Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)-
- Pyrrolidine, 2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, (2R)-, (2E)-2-butenedioate (1:1)
- Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)- (8CI)
- Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)-, fumarate (1:1)
- Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-
- Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-, (E)-2-butenedioate (1:1)
- Reconin
- Tavegil
- Tavegyl
- Tavist
- Telgin
- Telgin G
- Trabest
- Xolamin
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