CAS 1498305-51-3

N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite

Description:

N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite is a specialized chemical compound primarily used in the field of nucleic acid chemistry, particularly in the synthesis of oligonucleotides. This compound features several key structural characteristics: it contains a cytidine base modified at the N4 position with an acetyl group, which can influence its reactivity and stability. The 5'-O-DMT (dimethoxytrityl) group serves as a protective moiety that facilitates the stepwise synthesis of oligonucleotides by preventing premature reactions at the 5' hydroxyl group. The 2'-O-propynyl modification enhances the compound's properties, potentially improving its binding affinity and stability in biological systems. Additionally, the 3'-CE (cyanoethyl) phosphoramidite moiety is crucial for the incorporation of this building block into growing oligonucleotide chains during solid-phase synthesis. Overall, this compound is significant in the development of nucleic acid-based therapeutics and research applications, owing to its unique modifications that enhance oligonucleotide performance.

Formula: C₄₄H₅₂N₅O₉P

Synonyms:

• DMTr-2'-O-propargyl-rC(Ac)-3'-CE-Phosphoramidite
• N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite
• Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
• 2'-O-propargyl?Cytidine?(n-Ac)?CED?phosphoramidite
• DMT-2'-O-propargyl-C(Ac)-CE-Phosphoramidite

(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

CAS: 1498305-51-3

(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

Purity: 90%

Molecular weight: 825.9g/mol

Ref: 54-OR1065804

N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite

CAS: 1498305-51-3

N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite is an activator and antiviral agent that inhibits viral DNA synthesis by terminating the elongation step of viral DNA chain extension. N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite has a novel structure and is synthesized by modified chemical reactions. It can be used in the synthesis of oligonucleotides or as a building block for the synthesis of other nucleosides.

Formula: C₄₄H₅₂N₅O₉P

Purity: Min. 95%

Molecular weight: 825.89 g/mol

Ref: 3D-PA139177