CAS 149882-10-0

Lurtotecan

Description:

Lurtotecan is a synthetic compound classified as a topoisomerase I inhibitor, primarily investigated for its potential use in cancer therapy. It belongs to the camptothecin family, which is known for its ability to interfere with DNA replication and transcription by stabilizing the topoisomerase I-DNA complex, ultimately leading to cell death in rapidly dividing cancer cells. Lurtotecan exhibits a unique chemical structure that contributes to its pharmacological properties, including its solubility and stability. The compound has shown promise in preclinical studies, demonstrating efficacy against various tumor types. Its mechanism of action involves the induction of DNA damage, which triggers cellular apoptosis. Additionally, Lurtotecan's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile. Ongoing research aims to optimize its formulation and delivery methods to enhance its effectiveness while minimizing side effects. As with many investigational drugs, further clinical trials are necessary to fully establish its therapeutic benefits and potential applications in oncology.

Formula: C₂₈H₃₀N₄O₆

InChI: InChI=1S/C28H30N4O6/c1-3-28(35)20-11-22-25-18(14-32(22)26(33)19(20)15-38-27(28)34)17(13-31-6-4-30(2)5-7-31)16-10-23-24(12-21(16)29-25)37-9-8-36-23/h10-12,35H,3-9,13-15H2,1-2H3/t28-/m0/s1

InChI key: InChIKey=RVFGKBWWUQOIOU-NDEPHWFRSA-N

SMILES: C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=C(CN5CCN(C)CC5)C=6C(N4)=CC7=C(C6)OCCO7)COC1=O

Synonyms:

• 11H-1,4-Dioxino[2,3-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione, 8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-, (S)-
• (8S)-8-Ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-11H-1,4-dioxino[2,3-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione
• Lurtotecan
• GI 147211
• 11H-1,4-Dioxino[2,3-g]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione, 8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-, (8S)-

Lurtotecan

CAS: 149882-10-0

Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.

Formula: C₂₈H₃₀N₄O₆

Purity: 99.18%

Color and Shape: Soild

Molecular weight: 518.56

Ref: TM-T60163

Lurtotecan

CAS: 149882-10-0

Lurtotecan

Purity: ≥95%

Molecular weight: 518.56g/mol

Ref: 54-BUP04853