CAS 1499-29-2

methylenebis(phosphonic dichloride)

Description:

Methylenebis(phosphonic dichloride), with the CAS number 1499-29-2, is a chemical compound characterized by its phosphonic acid derivatives. It typically appears as a colorless to pale yellow liquid and is known for its high reactivity due to the presence of dichloride functional groups. This compound is primarily utilized in the synthesis of various phosphonic acid derivatives and as a reagent in organic chemistry. Its structure features two phosphonic dichloride groups linked by a methylene bridge, which contributes to its unique chemical properties. Methylenebis(phosphonic dichloride) is hygroscopic, meaning it can absorb moisture from the air, and it is sensitive to hydrolysis, leading to the formation of phosphonic acids upon reaction with water. Due to its reactivity, it must be handled with care, as it can release toxic gases upon decomposition. Its applications extend to fields such as agriculture, where it may be used in the formulation of herbicides and other agrochemicals, as well as in materials science for the development of flame retardants and corrosion inhibitors.

Formula: CH₂Cl₄O₂P₂

InChI: InChI=1/CH2Cl4O2P2/c2-8(3,6)1-9(4,5)7/h1H2

SMILES: C(P(=O)(Cl)Cl)P(=O)(Cl)Cl

Methylenebis(phosphonic dichloride)

CAS: 1499-29-2

Methylenebis(phosphonic dichloride)

Formula: CH₂Cl₄O₂P₂

Purity: ≥95%

Color and Shape: faint beige crystalline powder

Molecular weight: 249.78g/mol

Ref: 54-OR55273

Methylenebis(phosphonic Dichloride)

Controlled Product

CAS: 1499-29-2

Applications Methylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.
E0
References Kalek, M., et al.: Tetrahedron Lett., 46, 2417 (2005); Tanaka, K., et al.: Bioorg. Med. Chem. Lett., 20, 1355 (2010);

Formula: CH₂Cl₄O₂P₂

Color and Shape: Neat

Molecular weight: 249.78

Ref: TR-M304305

bis(dichlorophosphoryl)methane

CAS: 1499-29-2

Purity: 95

Molecular weight: 249.77000427246094

Ref: 10-F874359

Methylenebis(phosphonic dichloride)

CAS: 1499-29-2

Methylenebis(phosphonic dichloride) is a synthetic compound that is used in the synthesis of phosphonates. It has been shown to be toxic to mammalian cells, with an LD50 of 1.1 mM/mL for K562 cells and 5.5 mM/mL for fetal bovine cells. Methylenebis(phosphonic dichloride) has also been shown to have efficient cytotoxic activity against covid-19 pandemic virus (HIV). This compound has not been found to be mutagenic or carcinogenic in studies on mice, rats, or rabbits. It is thought that the cytotoxic effects are due to its ability to inhibit translation by binding to ribosomes and preventing the formation of polypeptides during protein synthesis.
Methylenebis(phosphonic dichloride) can also be used in synthetic chemistry as a precursor for other compounds such as phosphinic acid, phosphonic acid, and phosph

Formula: CH₂Cl₄O₂P₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 249.78 g/mol

Ref: 3D-FM160756

Phosphonic dichloride, P,P'-methylenebis-

CAS: 1499-29-2

Formula: CH₂Cl₄O₂P₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 249.7849

Ref: IN-DA001M43